Наукові праці. Кафедра гістології, цитології та ембріології

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Age-related changes in the cerebral hemispheres of male and female brains: a morphometric study using MRI brain scans
(Bulletin of Medical and Biological Research, 2024) Maryenko, N.; Мар'єнко, Наталія Іванівна
Understanding the differences in brain ageing between males and females and the varying sensitivity of morphometric parameters to ageing are crucial for developing algorithms and protocols for objective and quantitative brain morphology evaluation in clinical practice. The study revealed more pronounced changes in absolute cross-sectional area values corresponding to overall brain tissue with ageing in males. However, no significant sex difference was observed in the age dynamics of relative values. The ratio of two cross-sectional brain areas, considering sulcal content and excluding it, has been identified as the most sensitive parameter to age-related changes in both male and female brains. This ratio could serve as an additional morphometric parameter for diagnostic purposes in examining cerebral structure.
Anatomical variability of the alveolar process of the maxilla based on multislice computed tomography data
(2024) Shiyan, D.; Kysylenko, K.; Trach, O.; Трач, Ольга Олександрівна; Yurevych, N.; Lupyr, M.; Alekseeva, V.
Modern research methods, widely implemented in routine medical practice, open new horizons for the study of anatomical structures. The maxilla is one of the regions of the human skull that shows significant variability with age and gender. This is due to the peculiarities of tooth eruption and age-related changes in the periodontium and adjacent structures, which undoubtedly affect the structure of the alveolar process, sometimes drastically altering it over time. Aim: The aim of our study was to determine the anatomical variability of the alveolar process of the maxilla based on multislice computed tomography data. Materials and Methods: The research was conducted based on the results of 400 spiral computed tomography scans of males and females aged 18 to 95 years with detection of the anatomical variability of the alveolar process.
Applications of fractal analysis techniques in magnetic resonance imaging and computed tomography for stroke diagnosis and stroke-related brain damage: a narrative review
(Advanced Technology in Neuroscience, 2024) Maryenko, Natalia; Мар'єнко, Наталія Іванівна
This review provides an overview of the principles, characteristics, and main applications of the fractal analysis technique, focusing on its applications and perspectives in stroke diagnosis based on neuroimaging data. In stroke research, the fractal analysis technique has been used to characterize brain tissue, pathological foci, and the vascular network, providing critical diagnostic and prognostic information. Researchers have applied the fractal analysis technique to brain lesions resulting from ischemic strokes to conduct geometric analyses of lesion shapes, indicating its diagnostic and prognostic values. Overall, the fractal analysis technique in brain magnetic resonance imaging and computed tomography is an informative and sensitive imaging analysis method that, with further development, can significantly improve stroke diagnosis and prognosis on the basis of neuroimaging data.
Arbor vitae cerebelli: fractal properties and their quantitative assessment by novel “contour scaling” fractal analysis method (an anatomical study)
(Translational Research in Anatomy, 2024) Maryenko, Natalia; Мар'єнко, Наталія Іванівна; Stepanenko, Oleksandr; Степаненко, Олександр Юрійович
Arbor vitae cerebelli (tree-like branching white matter of the cerebellum) has a complex spatial configuration that is challenging to assess using conventional morphometric methods. This study proposes a fractal approach to describe and quantify the anatomy of Arbor vitae cerebelli. For this purpose, a new “contour scaling” method for fractal analysis of cerebellar white matter was developed. The fractal (Hausdorff) dimension, determined using the novel “contour scaling” method, quantitatively assesses the degree of branching of the cerebellar white matter. An increase in the absolute size of the cerebellum leads to a higher degree of branching of its white matter and an increase in the number of its constitutive components – white matter branches and folia.
Cortex and white matter of the cerebral hemispheres: anatomical correlations and age-related changes measured with fractal analysis
(2024-05) Maryenko, Nataliia; Мар'єнко, Наталія Іванівна; Stepanenko, Oleksandr; Степаненко, Олександр Юрійович
The aim of the present study was to determine the fractal dimension (FD) values of the cortex and white matter of the cerebral hemispheres using fractal analysis of two-dimensional magnetic resonance images, explore the anatomical correlations of the cortex and white matter FD, and study age-associated changes in the cortex and white matter. In this study, a negative correlation was found between the cortex and white matter FD values, influenced by anatomical factors such as the degree of gyrification. While the cortex FD values significantly decreased with age, age-related changes in the white matter FD values were relatively weak.
Definition of the range of variability of the linear parameters of the human skull depending on gender and craniotype in the age aspect
(2024) Melnyk, Bogdan; Мельник, Богдан Ігорович; Boiagina, Olga; Боягіна, Ольга Дмитрівна
The question of studying sexual dimorphism, age-related changes and aging of tissues, including bone tissue, is still relevant today. The rapid development of maxillofacial surgery and orthodontics requires an in-depth study of the features of skull formations depending on gender and craniotype. The purpose of our study was to determine the patterns of sexual dimorphism of craniometric indicators of the human skull depending on age. The material of the study was 125 CT scans of the head of men and women aged 25 to 85 without pathology of the bones of the skull, performed using a Neusoft NeuViz 16 Essence 16-Slice CT Scanner System. Visual analysis and craniometric measurements were performed using the Horos ver.4.0.1 program included in the computer tomography software and the Vidar Dicom Viewer ver. 3.3.1.9. It was established that the values of the linear dimensions of the skull, such as length, width and height, depend on the craniotype and gender of the person. The range of variability of the main indices of the skull was also determined. The most common combinations of skull types have been established.
Determination of the range of variability of the human orbital opening height and width according to computer tomography data
(Дніпровський державний медичний університет, 2024) Melnyk, B.; Boiagina, O.; Боягіна, Ольга Дмитрівна; Panasenko, V.; Панасенко, В'ячеслав Олексійович
Usage of computerized tomography scanning markedly expands now the ability for studying the features of the human skull structures. Morphometric studies play an important role in the identification of a person during a forensic medical examination, in determining the features of certain anatomical structures, including the orbit. Acquired during research findings may be useful in clinical medical practice when preparing for orbital reconstruction surgery after injuries or congenital malformations. Aim of study. Establishing the range of individual anatomical variability of the height and width of the human orbital opening depending on the craniotype and gender.
Establishing the range of variability of the longitudinal dimensions of the lower jaw in women with different craniotypes
(International Scientific Unity, 2024) Melnyk, Bohdan; Boiagina, Olga; Боягіна, Ольга Дмитрівна; Samosudova, Liudmyla; Самосудова, Людмила Вікторівна
In recent years, the areas of surgery related to the correction and plasticity of the bones of the facial skull have been developing rapidly, which in turn requires indepth knowledge of the individual anatomical variability of the structures of this area. Therefore, the further study of the peculiarities of the dimensions and relationships of the skull structures remains one of the most important problems of modern craniology. The purpose of the research is to determine the range of variability of the longitudinal dimensions of the lower jaw of women depending on the type of facial skull structure.
Establishing the range of variability of the width and height of the human visceral skull depending on the craniotype and gender
(Дніпровський державний медичний університет, 2024) Melnyk, B.; Boiagina, O.; Боягіна, Ольга Дмитрівна
The range of variability of the width and height of the facial part of the human skull, depending on the extreme forms of the structure, has been established. The results were obtained, according to which the linear dimensions of the skull that we studied are directly dependent on the craniotype: the largest indicators of the width of the facial part of the skull are characteristic of euryprozops, and the smallest – leptoprozops. It was determined that the most significant difference between the above-mentioned indicators, namely their increase in men compared to women, is characteristic of advanced age and old age. There were no statistically significant differences in the width and height of the facial skull in representatives of the same sex, but different age groups. Diagrams of the ratio of various types of facial skull structure according to the main facial index were created and the most common combinations of them with types of skull structure according to the cranial index were established.
Evaluation of cerebellar aging in mri images: fractal analysis compared to euclidean geometry-based morphometry
(Meta-Radiology, 2024) Maryenko, N.; Мар'єнко, Наталія Іванівна; Stepanenko, O.; Степаненко, Олександр Юрійович
This study aimed to identify age-related changes in the fractal dimensions of the cerebellum and compare the sensitivity of fractal analysis and conventional Euclidean geometry-based morphometry to cerebellar aging. The normal aging of the cerebellum involves not only absolute size alterations but also changes in the texture and spatial configuration of cerebellar tissue components, which can be quantitatively and objectively assessed by fractal analysis.
Fractal dimensions of the cerebral hemispheres: anatomical correlations, age-related changes, and application prospects in clinical practice
(Дніпровський державний медичний університет, 2024) Maryenko, N.; Мар'єнко, Наталія Іванівна
Fractal analysis is a promising image analysis method that can be used as a morphometric tool in neuromorphology, allowing for the quantitative assessment of the extent to which space is filled by structures with geometrically complex configurations. There are various types of fractal dimensions (FD) of brain structures, but data on the anatomical correlations of FD and the structural features of brain that affect FD values are lacking. The primary factors influencing different FD values are the structural complexity and age-related changes of the cerebral hemispheres. Structural complexity (the number and complexity of gyri) positively correlated with the FD of the cortex, digital skeleton, and contours, while showing negative correlations with the FD of the white matter. The FD of the cortex, the FD of the contour determined by contour smoothing method, and the FD of the brain tissue as a whole (FD of silhouettes) were the most sensitive to age-related changes. The most promising areas for the application of fractal analysis in clinical practice include the identification and quantitative characterization of atrophic changes, the differentiation of atrophy in normal versus pathological aging, and the diagnosis of brain malformations.
Individual anatomical variability of the anteroposterior lateral dimensions of the facial skull in mature adults
(Georgian medical news, 2024) Sosonna, L.; Boiagina, O.; Боягіна, Ольга Дмитрівна; Yurevych, N.; Schevtsov, O.; Avilova, O.; Konoval, N.; Sukhina, I.
Despite the significance of anatomical variability in various specialties, there is currently limited research dedicated to this topic. Most studies focus on the brain, with only a small number examining the human skull, primarily in relation to anatomical variability in childhood. Aim: Therefore, the aim of our work is to determine the individual anatomical variability of the lateral dimensions of the facial section of the adult human skull. Materials and methods: The study included 115 skulls of mature individuals, comprising 35 dry bone specimens from the anatomy museum collection and 80 results from human head CT scans without bone tissue pathologies. To detail the craniometric characteristics of the lateral surface of the facial section of the skull, polygons (polygons) were constructed with dividing of the facial section of the skull is into the orbital-frontal, nasal, and maxillary. The facial profilegram of the skull was formed as a set of predetermined dimensions between facial profile points, presenting a continuous line passing through points gl-n-rhi-ns-pr-id-pg, reflecting the shape, dimensions, and position of the cranial profile of mature adults regardless of sex or cranial type. Results: It was established that the longitudinal anteroposterior dimensions of the facial skull exhibit a certain range of variability in mature individuals depending on gender. For instance, the distance between the points gl-po (glabella-porion) reaches its maximum values in individuals with a brachycranial skull shape, ranging from 107 mm to 130 mm in men and from 104 mm to 128 mm in women. In individuals with a mesocranial skull shape, this parameter gradually decreases to 109-126 mm in men and 107-124 mm in women. A similar decrease is observed in those with a dolichocranial skull shape, where the range is 109-121 mm in men and 109-120 mm in women. The distance between n-po (nasion-porion) in brachycranial and mesocranial individuals remains within 96-123 mm and 102-123 mm, regardless of gender, indicating that this parameter is relatively stable. However, in dolichocranial individuals, this distance decreases to 104-115 mm. Conclusions: Individual anatomical variability of the anteroposterior lateral dimensions of the facial skeleton in mature individuals has been determined. A more in-depth analysis of the existing range of individual variability in the profile configuration of the facial skull was conducted using sagittal polygons. It was found that the polygons gl-po-n, n-po-rhi, and rhi-po-ns relate to the structure of the bony profile of the orbital-temporal and nasal regions of the facial skull, reflecting the upper, combined orbital-nasal section of the head.
Individual anatomical variability of the longitudinal dimensions of the lower jaw in men
(International Scientific Unity, 2024) Melnyk, B.; Boiagina, O.; Боягіна, Ольга Дмитрівна; Samosudova, L.; Самосудова, Людмила Вікторівна
The issue of studying individual anatomical variability of skull bones does not lose its relevance. In order to improve methods of diagnosis and treatment of various diseases and anomalies of skull development, it is very important to have complete information about individual anatomical variability of skull structures. This necessity is primarily associated with the rapid development of maxillofacial surgery and orthodontics. For the successful treatment of the patient, one cannot do without an in-depth study of the features of the bones: their thickness, linear dimensions, craniotopographic relationships between the structures of the skull depending on gender and craniotype.
Planimetric analysis of individual variability and sexual dimorphism of the orbital opening
(Baltija Publishing, 2024) Melnyk, B.; Boiagina, O.; Боягіна, Ольга Дмитрівна; Panasenko, V.; Панасенко, В'ячеслав Олексійович
Morphometric studies, which are carried out using computer tomography methods, play an important role in determining the features of certain anatomical structures, including orbit. It has recently been described that aging of the facial bones is mainly a consequence of volume loss and morphological changes in the orbit, midface and mandible. Some scientists believe that age-related changes in the facial skeleton are mainly concentrated in the orbit, upper and lower jaws. They claim that the size of the orbit tends to increase with age. Toothless individuals of both sexes have wider orbit and shorter maxilla and mandible height. Thus, the problem of studying sexual dimorphism and age-related changes in skull structures, including the orbit, remains relevant.
Quantitative assessment of structural complexity in human cerebellum through analysis of skeletonized mr images: anatomical correlations, sex differences, and agerelated changes
(Acta Morphologica et Anthropologica, 2024) Maryenko, Nataliia; Мар'єнко, Наталія Іванівна; Stepanenko, Oleksandr; Степаненко, Олександр Юрійович
The present study provides a quantitative assessment of the human cerebellum structural complexity using analysis of skeletonized images. Magnetic resonance images from 100 apparently healthy individuals (aged 18-86 years) were examined. Following segmentation, the images were skeletonized, and quantitative analysis of the digital skeletons was conducted. The following parameters were determined: number of branches and their junctions, end-point, slab and junction pixels, average and maximum branch length, triple and quadruple points. Sex differences were assessed. Correlation analysis included determining the relationships between the studied parameters and age, morphometric parameters derived from Euclidean and fractal geometries, as well as the same parameters of the digital skeletons identified in the cerebral hemispheres. In conclusion, quantitative analysis of digital cerebellar skeletons offers advantages for assessing the structural complexity of the cerebellum. This method and the results of the present study can be applied in diagnosing cerebellar malformations and distinguishing between malformations and atrophic alterations.
Range of variability of the morphometric indicators of the piriform aperture of men depending on craniotype
(Приватний вищий навчальний заклад «Харківський міжнародний медичний університет», 2024) Boiagina, O.; Боягіна, Ольга Дмитрівна; Melnyk, B.; Samosudova, L.; Самосудова, Людмила Вікторівна
The maxillofacial region is an anatomically complex area that includes structures of a peculiar shape. This can add difficulty to their display on tomograms and complicate the interpretation of these images. Therefore, perfect knowledge of the tomographic anatomy of the maxillofacial region is absolutely necessary. The aim was to study the morphometric parameters of the piriform aperture of men depending on the craniotype. Conclusions. 1. The range of variability of the height, width, perimeter and area of the piriform aperture of men is determined. 2. It was established that the investigated parameters do not depend on the type of facial skull structure.
The use of data analytics in public administration for corruption prevention during hybrid warfare
(2024) Shevchenko, Nataliia; Marukhlenko, Oksana; Trach, Olha; Трач, Ольга Олександрівна; Shvedenko, Pavlo; Dubovych, Olesia
The relevance of the selected theme is stipulated by the destructive effect of corruption on the social structure of society and the weakening of the rule of law. Corruption schemes as an instrument of geopolitics are used as a part of the foreign policy arsenal of authoritarian states such as Russia. Under such circumstances, data analytics provides researchers and public society with a large volume of analytical instruments, enabling comprehensive monitoring of governments. Such monitoring enhances the efficiency of corruption prevention in public administration. The article aims to determine the data analytics method for corruption prevention in public administration during hybrid warfare. Using the methods of content analysis, historical, abstract-logical methods, we found how data analytics can contribute to effective corruption prevention in public administration. Perspective and appropriate methods of data analytics used for corruption prevention in public administration were found. Based on the results of the conducted study, recommendations for improvement of the use of data analytics in public administration for corruption prevention during hybrid warfare were offered. The perspective of further studies includes research on introducing data analytics in the everyday work of particular state institutions.