Cortex and white matter of the cerebral hemispheres: anatomical correlations and age-related changes measured with fractal analysis

Abstract

The aim of the present study was to determine the fractal dimension (FD) values of the cortex and white matter of the cerebral hemispheres using fractal analysis of two-dimensional magnetic resonance images, explore the anatomical correlations of the cortex and white matter FD, and study age-associated changes in the cortex and white matter. In this study, a negative correlation was found between the cortex and white matter FD values, influenced by anatomical factors such as the degree of gyrification. While the cortex FD values significantly decreased with age, age-related changes in the white matter FD values were relatively weak.