Наукові праці. Кафедра інфекційних хвороб, дитячих інфекційних хвороб, фтизіатрії та пульмонології
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Item Concomitant pathology of patients with COVID-19 infection(Perfect Publishing, 2024) Andrusovych, InnaMany studies have shown that a more severe course of COVID-19 is associated with the presence of comorbidities. Thus, the risk of hospitalization in patients with bronchial asthma is 1.5 times higher, and in patients with chronic kidney disease and diabetes mellitus - 4 and 3 times higher, respectively. Among the risk factors that significantly affect the deterioration of COVID-19, the researchers consider the following: older age, male gender, and comorbidities. For example, in the presence of concomitant hypertension, the risk of mortality increases by at least 1.7-3.5 times, and in the presence of grade I-II obesity - by 3 times. According to Pranata et al, cardiovascular and cerebrovascular pathology was the leading comorbidity in patients with COVID-19. Another meta-analysis by Pranata et al. showed the impact of concomitant hypertension on the course of COVID-19: hypertension was significantly associated with total negative outcomes of COVID-19: hazard ratio (HR) = 2.11 [95.0% confidence intervals (CI) 1.85-2.40], p < 0.001.Item Damage to the respiratory system of patients SARS-CoV-2 associated with COVID-19 infection(Міжнародний центр наукових досліджень, 2024) Andrusovych, InnaCorona virus disease (COVID-19) is associated with a number of clinical conditions mainly of the respiratory system, including both mild lesions of the upper respiratory tract and severe viral pneumonia. Manifestations of interstitial pneumonia are determined among at least 14.0% of infected patients, which has a significant chance of developing into a severe acute respiratory syndrome with subsequent need for intensive therapy. In addition, damage to peripheral pulmonary vessels and vessels involved in gas exchange significantly affects the balance of ventilation and perfusion, which causes the development of hypoxemia and requires a change in the patient's position during oxygenation.Item Determination of the degree of inflammatory response in patients with COVID-19 infection by interleukin-6 levels(MDPC Publishing, 2024) Andrusovych, InnaAn inflammatory reaction and subsequent severe organ damage play an undeniable role in the pathogenesis of disorders in patients with COVID-19 infection. Clinically, this is manifested by severe acute respiratory syndrome, which is characterized by diffuse damage to the alveoli at the level of hyaline membranes. The immune response in this case can manifest itself in the form of a cytokine storm: in the vast majority of patients, there is a significant increase in the levels of interleukin (IL)-6, IL-17A and tumor necrosis factor-α.Item Dynamics of clinical and laboratory indicators of patients with COVID-19 against the backdrop of treatment(2024) Andrusovych, InnaThe article presents the results of the analysis of the dynamics of the main indicators of the blood coagulation system and cytokines (IL-6, D-dimers, C-reactive protein and procalcitonin) on the background of thromboprophylaxis in patients with COVID-19. The aim of our study was to determine the dynamics of the main indicators of the blood coagulation system and cytokines in the setting of thromboprophylaxis. The study was conducted at the Department of Infectious and Pediatric Infectious Diseases, Parasitology, Phthisiology and Pulmonology of the Kharkiv National Medical University and at the Municipal Non-Profit Enterprise "Kharkiv Regional Infectious Diseases Hospital" of the Kharkiv Regional Council, in 2020–2024 with compliance of the existing recommendations of bioethical norms and rules. All patients singed informed consent. We examined 179 patients aged 20–88 years (average age of [58.75±13.82] years) with COVID-19. The diagnosis of COVID-19 was confirmed by enzyme-linked im-munosorbent assay and polymerase chain reaction. Medical and statistical calculations were performed using the SPSS 25.0 software package. The mean value and standard square devia-tion were calculated. The probability of differences was determined using the Mann-Whitney U-test with a threshold value of statistical significance of p=0.05. According to the results of the study, a significant (p<0.001) dynamic of restoration of D-Dimers’ levels was noted against the background of the applied therapy (on days 9–10, a decrease of 166.3 Fibrinogen Equivalent Unit (FEU), ng/ml, and on days 12–15 – of 376.7 FEU, ng/ml) and procalcitonin (on days 6–7 the content was by 0.04 ng/ml, p=0.006; on days 10–11 – 0.01 ng/ml, p<0.001; on days 12–15 – also 0.01 ng/ml, p=0.027).Item Features of blood coagulation indicators in surgical patients with a confirmed diagnosis of COVID- 19(European Surgery, 2024-05-16) Andrusovych, Inna; Korolevska, Anna; Komarchuk, I.Timely and accurate assessment of the state of the hemostasis system in patients with the different severity of the course of COVID-19 is the key to the correct appointment appropriate volume of anticoagulant therapy in order to prevent complications disease. Thromboelastography is a non-invasive method evaluation of the hemostasis system – not only provides data on the state of the links thrombus formation, but also the processes of fibrinolysis, a comprehensive assessment of which can contribute to the personalized selection of anticoagulant therapy. The aim of the research. Determine the relationship between the difficulty of the course and the tension of the system hemostasis in patients with different course of the COVID-19 coronavirus disease.Item Lesions in the functional state of the cardiovascular system of patients with COVID-19 infection(MDPC Publishing, 2024) Andrusovych, InnaThe coronavirus family has been known since the 20th century, but until the outbreak of severe acute respiratory syndrome coronavirus disease (COVID-19) and Middle East respiratory syndrome (MERS-CoV), they were not given appropriate clinical and epidemiological significance. Thus, the most severe respiratory diseases were caused by 3 beta coronaviruses, in particular SARS-CoV, SARS-CoV-2 and MERS-CoV. Although most patients with COVID-19 have a predominantly respiratory tract involvement, a certain cohort has a more severe course of the disease with the development of systemic involvement characterized by resistant fever, acute lung injury and severe acute respiratory syndrome, shock and subsequent multiorgan failure. The combination of diffuse intravascular coagulation with the formation of large-caliber vascular thrombosis is also associated with the development of multiple organ failure. Mortality rates from COVID-19 reach at least 10.0%.Item Value of clinical blood analysis indicators of patients with COVID-19 infection(SPC “Sci-conf.com.ua”, 2024) Andrusovych, InnaEmerging in late 2019, the coronavirus disease (COVID-19) has quickly become global with extraordinary rates of morbidity and mortality. The World Health Organization defines COVID-19 as a severe acute respiratory syndrome caused by coronavirus type 2 (SARS-CoV-2). This is the third zoonotic coronavirus that has caused an epidemic in recent years. Bats can be considered the primary reservoir of infection, as the virus isolated from them has a high affinity to SARS-CoV-2. This type of coronavirus primarily affects the epithelium of the respiratory tract, entering the cells through interaction with the receptors of the angiotensin 2-converting enzyme.