Кафедра медичної та біоорганічної хімії
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Item Anti-Inflammatory Effect of Coxibs and their Compositions with Caffeine on the Level of Conjugated Dienes in the Formalin-Induced Edema Model(Turkish Chemical Society, 2022) Syrova, Ganna; Petiunina, Valentina; Savelieva, Olena; Tishakova, Tetyana; Lukianova, LarysaThe development of novel pharmaceutical compositions, which are effective in the treatment of different inflammatory diseases and have a minimum number of side effects is very relevant. The aim of the present study was biochemical confirmation of anti-inflammatory activity of new pharmaceutical compositions comprising coxibs and caffeine. The level of conjugated dienes as primary products of lipid peroxidation has been evaluated in the plasma of rats at the acute inflammation caused by formalin. The white male rats of WAG line were used. The content of conjugated dienes was determined by spectrophotometric method. It was shown that combinations of caffeine and coxibs showed statistical significant decrease in the content of conjugated dienes in the rats’ blood plasma. Caffeine enriched anti-inflammatory action of coxibs effectively.Item Creation of anti-inflammatory pharmaceutical compositions (review)(2022-11-13) Syrova, Ganna; Petyunina, Valentina; Makarov, Volodimir; Lukіаnova, Larysa; Chalenko, NataliaThe review article summarizes the data of literature and our own research on the creation of more effective and safe domestic combined drugs with a pronounced anti-inflammatory and analgesic effect. Untimely treatment of inflammatory processes often leads to long-term incapacity and even disability, so today there is an active search for new effective and safe domestic combination drugs with pronounced anti-inflammatory and analgesic effects. Due to the constant search for innovative drugs the treatment of a significant number of diseases and pathological conditions with existing drugs remains ineffective or causes addiction and a large number of side effects. As a result, inflammatory processes can be accompanied by severe pain, spasms, increased convulsive activity of the brain, other disorders, so non-narcotic analgesics and nonsteroidal anti-inflammatory drugs are combined with other agents that can cause complementary effects or potentiate each other's effects. Caffeine is a useful adjuvant of nonsteroidal anti-inflammatory drugs of various chemical structures in terms of anti-inflammatory and analgesic effects. The article presents a literature review of the current state of treatment of inflammation and pain, conducting research to expand the therapeutic capabilities of known pharmaceuticals, the creation of pharmaceutical compositions of nonsteroidal anti-inflammatory drugs with caffeine.Item Experimental study of the antipyretic effect of oxicams and their compositions with caffeine(2018-09-30) Syrova, Ganna; Lukianova, Larysa; Kalinenko, Olga; Vodolazhenko, Maria; Petiunina, ValentinaThe experimental study of the influence of caffeine on the antipyretic activity of oxicams in rats was carried out. Meloxicam, piroxicam and their adjuvant caffeine were selected as drugs. According to the results of experimental studies, it was found that meloxicam has the highest antipyretic activity (89,24 %) in 3 hours after administration and exceeded the antipyretic activity of the reference drug. Addition of caffeine to meloxicam did not promote increasing of the meloxicam antipyretic activity, so this composition is considered inappropriate in relation to its antipyretic effect. The antipyretic activity of piroxicam was lower comparing to the reference drug diclofenac sodium. Addition of caffeine to piroxicam promotes increasing of the piroxicam antipyretic activity in 3 hours after administration of the drug. This exceeded the piroxicam antipyretic activity in 1,3 times but did not reach diclofenac sodium activity. The results of experimental studies can become the basis for the creation of new domestic combined medicines.Item The experimental research on the antiinflammatory action of the new piroxicamcaffeine pharmaceutical composition(2018) Syrova, Ganna; Lukianova, Larysa; Chalenko, NataliaConducting an experimental research on laboratory rats subjected to endogastric injections, our scientists have explored the influence of the non-steroid anti-inflamatory drug from the oxicam group piroxicam (4-hydroxo-2-methyl-N-pyridine-2-il)-2H-1,2-benzothiazine-3-carboxamide1,1- dioxyde), a well-known adjuvant of non-narcotic analgetics and non-steroid anti-inflamatory drugs such as caffeine (1,3,7-trimethylxanthine)and the two-component piroxicam-caffeine pharmaceutical composition on the rats’ anti-exudative activity under formalin edema. The analysis of the results of the experimental researches points to the fact that caffeine promotes the anti-exudative action of piroxicam in the rats under formalin edema. The above-mentioned experimental researches allow us to come to the conclusion that due to its vasoconstrictive effect caffeine performs as an adjuvant to piroxicam (a non-steroid anti-inflamatory drug from the oxicam group) concerning the anti-exudative activity. The results of the research can become a basis for the development of new combined drugs in Ukraine.Item The experimental study of pharmaceutical composition piroxicam and caffeine(Scientific Educational Center Warsaw, Poland, 2017-11-18) Syrovaya, Anna; Lukianova, Larysa; Kolesnyk, Maria; Adamu, IsaakaIn an experiment on rats, the effects of a non-steroidal anti-inflammatory agent of the group of oxicams piroxicam, caffeine and their composition on emotional-behavioral reactions under formalin edema were conducted. Evaluation of drug’s and their compositions influence on characteristics of animal’s behavior was done by comparison remedies with control and with formalin edema. Observation of the parameters of routine research activity in the "open field" test and the multi-parameter method for evaluating anxiety-phobic states was carried out according to the generally accepted method. The analysis of the results of experimental studies indicates that caffeine increases the activity of piroxicam relatively to horizontal and vertical motion activity, cognitive activity, grooming and the number of urinations in rats under formalin edema. The results of research can be the basis for the development of new domestic combined medicines.Item Experiments on new pharmacological compositions under formalin edema(2016) Lukianova, LarysaThe experiment on rats explores the influence of nonsteroid anti-inflammatory drugs with various chemical structure, caffeine and their compositions on behavioral emotional reactions under formalin edema. The analysis of results of experimental researches shows, that caffeine potentiates the action of diclofenac sodium and ibuprofen concerning the horizontal and vertical motion activity and grooming in rats under formalin edema.Item Experiments on the influence of organic compounds with nitrogen and their compositions on the emotional-behavioral reactions of laboratory animals under formalin edema(USA: PCHHAX, 2016-08) Lukianova, LarysaThe experiment on laboratory animals explores their reference and exploratory activity while injecting organic compounds with nitrogen: caffeine paracetamol and carbamazepine and their compositions under formalin edema. The analysis of the results of our experiments shows that caffeine potentiates horizontal and vertical impellent activity and stimulates rats’ cognitive activity.Item Experimental substantiation for new medicinal compositions design(ORT Publishing, 2016) Syrovaya, Anna; Grabovetskaya, EvgeniyaAnalgesic and antiexudative activities of paracetamol and carbamazepine combinations with caffeine are examined in the experiment on laboratory rats. It is shown that caffeine potentiates antiexudative and analgesic activities of paracetamol and carbamazepine. The composition of paracetamol with caffeine is found to be the most effective among all investigated compounds.Item Experimental study of caffeine influence on antiexudative activity of known NSAIDs of different chemical structure(2015-09) Syrovaya, Anna; Grabovetskaya, EvgeniyaAntiexudative activity of combinations of some anti-inflammatory drugs with caffeine is shown in the experiment. It is found that caffeine potentiates antiexudative activity of diclofenac sodium, ibuprofen and paracetamol. It is discovered that the composition of caffeine with ibuprofen has more intensive antiexudative effect than the composition of caffeine with diclofenac sodium and paracetamol.Item From macro- to microcrystals(KhNMU, 2015-05) Dyadichev, Oleksiy; Grabovetskaya, Evgeniya