Кафедра гістології, цитології та ембріології
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Item Age-related changes in the cerebral hemispheres of male and female brains: a morphometric study using MRI brain scans(Bulletin of Medical and Biological Research, 2024) Maryenko, N.; Мар'єнко, Наталія ІванівнаUnderstanding the differences in brain ageing between males and females and the varying sensitivity of morphometric parameters to ageing are crucial for developing algorithms and protocols for objective and quantitative brain morphology evaluation in clinical practice. The study revealed more pronounced changes in absolute cross-sectional area values corresponding to overall brain tissue with ageing in males. However, no significant sex difference was observed in the age dynamics of relative values. The ratio of two cross-sectional brain areas, considering sulcal content and excluding it, has been identified as the most sensitive parameter to age-related changes in both male and female brains. This ratio could serve as an additional morphometric parameter for diagnostic purposes in examining cerebral structure.Item Anatomical predictions of development of rhinosinusitis and its complications(ХНМУ, 2020) Alieksieieva, Victoriia; Алєксєєва, Вікторія Вікторівна; Алексеева, Виктория ВикторовнаBackground. The anatomical structure of the paranasal sinuses of a person predetermines the risk of development, diversity of presentation, possibility of complications and features of surgical treatment of rhinosinusitis. Objective: of our study was to determine the thickness and density of the walls of the maxillary and frontal sinuses, which are potentially dangerous in terms of the development of complications. Materials and methods: Our study involved 121 subjects without any ENT diseases, who underwent SCT examination due to the reasons that were not related to abnormalities of ENT organs. Thickness and density in the region of the lower (orbital) wall and posterior (cerebral) wall of the frontal sinus were calculated. Results and Discussion. The maximum density was characteristic of the lower wall of the frontal sinus under physiological conditions and appeared 107.96 ± 201.64 Hu, the minimum for the lower wall was -29.98 ± 208.54 Hu. The thickness of the bone tissue in the frontal sinus was 4.05 ± 2.04 mm. Conclusion. The minimum density and thickness of the lower and posterior walls of the frontal sinus and upper and lower walls of the maxillary sinus was established under physiological conditions. The density of the posterior wall was found to be 25.4% lower than the density of the lower wall, and the thickness 22.2% lower.Item Anatomical structure of frontal and maxillary sinuses(2020) Алєксєєва, Вікторія Вікторівна; Алексеева, Виктория Викторовна; Alieksieieva, Victoriia; Gargin, VitaliyItem Anatomical variability of the alveolar process of the maxilla based on multislice computed tomography data(2024) Shiyan, D.; Kysylenko, K.; Trach, O.; Трач, Ольга Олександрівна; Yurevych, N.; Lupyr, M.; Alekseeva, V.Modern research methods, widely implemented in routine medical practice, open new horizons for the study of anatomical structures. The maxilla is one of the regions of the human skull that shows significant variability with age and gender. This is due to the peculiarities of tooth eruption and age-related changes in the periodontium and adjacent structures, which undoubtedly affect the structure of the alveolar process, sometimes drastically altering it over time. Aim: The aim of our study was to determine the anatomical variability of the alveolar process of the maxilla based on multislice computed tomography data. Materials and Methods: The research was conducted based on the results of 400 spiral computed tomography scans of males and females aged 18 to 95 years with detection of the anatomical variability of the alveolar process.Item Anatomical variants of the structure of the coronary arteries of the heart(ТДМУ, 2013-10) Масловський, Сергій Юрійович; Масловский, Сергей Юрьевич; Maslovsky, Sergey; Дуденко, Владимир Григорьевич; Дуденко, Володимир Григорович; Dudenko, Volodymyr; Бондаренко, Д.А.; Бондаренко, Д.А.; Bondarenko, D.Item Anatomo-morphometric features of human renal pyramids(ТДМУ, 2013-10) Масловський, Сергій Юрійович; Масловский, Сергей Юрьевич; Maslovsky, Sergey; Дуденко, Володимир Григорович; Дуденко, Владимир Григорьевич; Dudenko, Volodymyr; Шуба, Д.Г.; Шуба, Д.Г.; Shuba, D.Item Applications of fractal analysis techniques in magnetic resonance imaging and computed tomography for stroke diagnosis and stroke-related brain damage: a narrative review(Advanced Technology in Neuroscience, 2024) Maryenko, Natalia; Мар'єнко, Наталія ІванівнаThis review provides an overview of the principles, characteristics, and main applications of the fractal analysis technique, focusing on its applications and perspectives in stroke diagnosis based on neuroimaging data. In stroke research, the fractal analysis technique has been used to characterize brain tissue, pathological foci, and the vascular network, providing critical diagnostic and prognostic information. Researchers have applied the fractal analysis technique to brain lesions resulting from ischemic strokes to conduct geometric analyses of lesion shapes, indicating its diagnostic and prognostic values. Overall, the fractal analysis technique in brain magnetic resonance imaging and computed tomography is an informative and sensitive imaging analysis method that, with further development, can significantly improve stroke diagnosis and prognosis on the basis of neuroimaging data.Item Arbor vitae cerebelli: fractal properties and their quantitative assessment by novel “contour scaling” fractal analysis method (an anatomical study)(Translational Research in Anatomy, 2024) Maryenko, Natalia; Мар'єнко, Наталія Іванівна; Stepanenko, Oleksandr; Степаненко, Олександр ЮрійовичArbor vitae cerebelli (tree-like branching white matter of the cerebellum) has a complex spatial configuration that is challenging to assess using conventional morphometric methods. This study proposes a fractal approach to describe and quantify the anatomy of Arbor vitae cerebelli. For this purpose, a new “contour scaling” method for fractal analysis of cerebellar white matter was developed. The fractal (Hausdorff) dimension, determined using the novel “contour scaling” method, quantitatively assesses the degree of branching of the cerebellar white matter. An increase in the absolute size of the cerebellum leads to a higher degree of branching of its white matter and an increase in the number of its constitutive components – white matter branches and folia.Item Atrophic age-related changes in cerebral hemispheres: Euclidean geometry based morphometry of MRI brain scans(2023) Мар'єнко, Наталія Іванівна; Maryenko, Nataliia; Степаненко, Олександр Юрійович; Stepanenko, OleksandrThe aim of the present study was to conduct a comprehensive morphometric analysis of two-dimensional MRI brain images and determine the simple morphometric parameters of the cerebral hemispheres that best characterize quantitatively brain atrophic changes in normal aging. This study analyzed MRI brain scans from 100 apparently healthy individuals (44 males and 56 females) aged 18 to 86 years (mean age 41.72±1.58 years). For each brain investigation, five tomographic sections were selected, including four coronal and one axial. The perimeter, area values, and their derivative indices were determined. The study has shown that the parameter most sensitive to aging changes was the ratio of two area values: the area corresponding specifically to cerebral tissue and the area that captures the cerebral tissue and the sulcal content. The results of the present study can be used in clinical practice for the quantitative assessment of age-related atrophic changes in cerebral hemispheres.Item Auto nosodes from apoptotic cells of the buccal epithelium(2016) Карамишев, Василь Дмитрович; Карамышев, Василий Дмитриевич; Karamyshev, Vasiliy; Панасенко, В'ячеслав Олексійович; Панасенко, Вячеслав Алексеевич; Panasenko, Viacheslav; Клочко, Наталія Іванівна; Клочко, Наталия Ивановна; Klochko, NataliyaItem Blood(2013-04-10) Степаненко, Олександр Юрійович; Степаненко, Александр Юрьевич; Stepanenko, OleksandrItem Bone(2013-04-08) Карамишев, Василь Дмитрович; Карамышев, Василий Дмитриевич; Karamyshev, VasiliyItem Cartilage(2013-04-02) Карамишев, Василь Дмитрович; Карамышев, Василий Дмитриевич; Karamyshev, VasiliyItem Characterization of white matter branching in human cerebella: quantitative morphological assessment and fractal analysis of skeletonized MR images(2021) Maryenko, Nataliia; Stepanenko, OleksandrIntroduction: The aim of the present study was to investigate branching characteristics of the human cerebellar white matter by the means of findings obtained from the quantitative morphological assessment and fractal analysis of the skeletonized MR images of the human cerebellum. Methods: Thirty individuals with no apparent brain pathology (15 males and 15 females, ranging from 18 - 30 years of age) participated in this study. Their normal T2-weighted MR images of the cerebellar vermis (midsagittal plane) were examined. The skeletonizing procedure and subsequent quantitative morphological assessment of the acquired skeletonized MR images were performed. The following parameters were determined: the number of branches, the number of junctions, the amount of end-point voxels, junction voxels and slab voxels, the average and maximum branch lengths, the longest-shortest patch length, and the number of triple and quadruple points. Additionally, the individual branches of the obtained digital skeletons of the cerebellar white matter were examined and the following parameters were assessed: branch length variability, Euclidean distance, and branch length/Euclidean distance ratio. A fractal analysis was performed using the box counting method prior to and after the MR image skeletonizing procedure. The values of the fractal dimensions (FD) of both skeletonized and non-skeletonized MR images were calculated.Results:It was established that the cerebella, which had the maximum values of the FD, possessed a large number of small branches approximately equal in length and which were connected by numerous junctions, forming numerous endpoints. Those cerebella, which had higher values of the average branch length and greater branch length variability, showed lower values of the FD. The key characteristics of the digital skeleton that determined the values of the FD of the cerebellum and its skeletonized MR images were the number of branches and the number of junctions that had the strongest correlational relationships with the FD of the skeletonized MR images. We submitted a proposition to consider the number of branches and amount of junctions as a diagnostic criterion in the determination of normal values of the FD. Conclusions: The obtained data can be used as diagnostic criteria in assessment of the orphofunctional state of the cerebellum using magnetic resonance imaging (MRI) technique.Item Clusters of fractal dimension of the human cerebellum (magnetic resonance imaging study)(2020) Мар’єнко, Наталія Іванівна; Марьенко, Наталия Ивановна; Maryenko, NataliiaItem Comparative analysis of fractal dimensions of human cerebellum: impact of image preprocessing and fractal analysis methods(2022) Maryenko, Nataliia; Stepanenko, OleksandrThe aim: To compare the values of the fractal dimensions of human cerebellum obtained using different algorithms of image preprocessing and different methods of fractal analysis. Materials and methods: The study involved 120 people without structural changes in the brain (age 18-86 years, 55 men and 65 women). T1- and T2-weighted MR brain images were studied. Fractal analysis was performed using box counting and pixel dilatation methods. Fractal dimensions of cerebellar tissue as a whole, cerebellar cortex and its individual layers, cerebellar white matter were measured and compared to each other and to fractal dimension of cerebellar white matter determined in cadaveric cerebella. Results: It was no significant difference between fractal dimension values of cerebellar tissue as a whole measured on T1 and T2 weighted magnetic resonance images of cerebellum, and fractal dimension values measured on the same images using different methods of fractal analysis – pixel dilatation and box counting. T2 weighted images are preferable for fractal analysis of different components of cerebellar tissue. Segmentation according to pixel luminance is the preferable image preprocessing method for fractal analysis of cerebellar cortex as a whole, individual cortical layers and cerebellar tissue as a whole; skeletonizing of cerebellar magnetic resonance images is the preferable method of the image preprocessing for fractal analysis of cerebellar white matter. Conclusions: The algorithm of image preprocessing, magnetic resonance imaging sequence and method of fractal analysis should be chosen according to aim of quantitative study of cerebellar magnetic resonance images and features of the studied structure of cerebellum.Item Comparative clinical and morphological analysis of the periodontitis of different genesis(Видавництво ХНМУ, 2015) Деєва, Тетяна Володимирівна; Деева, Татьяна Владимировна; Deieva, Tetiana; Babay, Oksana; Merkulova, Yu.Модель пародонтита при введении бактериального эндотоксина позволяет направленно вызывать у животных комплекс воспалительно-дистрофических изменений пародонта, типичных для пародонтопатий у человека и патогномоничных пародонтиту человека, обосновывает целесообраз-ность использования данной модели при изучении пародонтопротекторной активности новых лекарственных средств.Item Congenital atresia of the digestive system(ХНМУ, 2020-01) Koltsova, Larysa; Кольцова, Лариса Вячеславовна; Кольцова, Лариса В'ячеславівна; Konoplia, LinaItem Connective tissue(2013-03-25) Степаненко, Олександр Юрійович; Степаненко, Александр Юрьевич; Stepanenko, OleksandrItem Connective tissue Blood Cartilage Bone(2012) Шестітко, Ірина Іванівна; Шеститко, Ирина Ивановна; Shestitko, Irene