Кафедра медичної та біоорганічної хімії
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Item Experimental study of the antipyretic effect of oxicams and their compositions with caffeine(2018-09-30) Syrova, Ganna; Lukianova, Larysa; Kalinenko, Olga; Vodolazhenko, Maria; Petiunina, ValentinaThe experimental study of the influence of caffeine on the antipyretic activity of oxicams in rats was carried out. Meloxicam, piroxicam and their adjuvant caffeine were selected as drugs. According to the results of experimental studies, it was found that meloxicam has the highest antipyretic activity (89,24 %) in 3 hours after administration and exceeded the antipyretic activity of the reference drug. Addition of caffeine to meloxicam did not promote increasing of the meloxicam antipyretic activity, so this composition is considered inappropriate in relation to its antipyretic effect. The antipyretic activity of piroxicam was lower comparing to the reference drug diclofenac sodium. Addition of caffeine to piroxicam promotes increasing of the piroxicam antipyretic activity in 3 hours after administration of the drug. This exceeded the piroxicam antipyretic activity in 1,3 times but did not reach diclofenac sodium activity. The results of experimental studies can become the basis for the creation of new domestic combined medicines.Item The experimental research on the antiinflammatory action of the new piroxicamcaffeine pharmaceutical composition(2018) Syrova, Ganna; Lukianova, Larysa; Chalenko, NataliaConducting an experimental research on laboratory rats subjected to endogastric injections, our scientists have explored the influence of the non-steroid anti-inflamatory drug from the oxicam group piroxicam (4-hydroxo-2-methyl-N-pyridine-2-il)-2H-1,2-benzothiazine-3-carboxamide1,1- dioxyde), a well-known adjuvant of non-narcotic analgetics and non-steroid anti-inflamatory drugs such as caffeine (1,3,7-trimethylxanthine)and the two-component piroxicam-caffeine pharmaceutical composition on the rats’ anti-exudative activity under formalin edema. The analysis of the results of the experimental researches points to the fact that caffeine promotes the anti-exudative action of piroxicam in the rats under formalin edema. The above-mentioned experimental researches allow us to come to the conclusion that due to its vasoconstrictive effect caffeine performs as an adjuvant to piroxicam (a non-steroid anti-inflamatory drug from the oxicam group) concerning the anti-exudative activity. The results of the research can become a basis for the development of new combined drugs in Ukraine.Item The experimental study of pharmaceutical composition piroxicam and caffeine(Scientific Educational Center Warsaw, Poland, 2017-11-18) Syrovaya, Anna; Lukianova, Larysa; Kolesnyk, Maria; Adamu, IsaakaIn an experiment on rats, the effects of a non-steroidal anti-inflammatory agent of the group of oxicams piroxicam, caffeine and their composition on emotional-behavioral reactions under formalin edema were conducted. Evaluation of drug’s and their compositions influence on characteristics of animal’s behavior was done by comparison remedies with control and with formalin edema. Observation of the parameters of routine research activity in the "open field" test and the multi-parameter method for evaluating anxiety-phobic states was carried out according to the generally accepted method. The analysis of the results of experimental studies indicates that caffeine increases the activity of piroxicam relatively to horizontal and vertical motion activity, cognitive activity, grooming and the number of urinations in rats under formalin edema. The results of research can be the basis for the development of new domestic combined medicines.