Кафедра медичної та біоорганічної хімії
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Item Study of analgesic and anti-exudative activity of compositions n-(3,4-dimethoxyphenyl)-2- [4-amino-5-(pyridine-4-yl)-4h-1,2,4-triazole-3-ylthio]acetamide in experiment(Perfect Publishing, 2023-03) Chalenko, Natalya; Demchenko, Anatolii; Syrova, Ganna; Levashova, Olga; Kozub, Svitlana; Kozub, PavloItem Academic integrity in higher education(Potere della ragione Editore. Rome, 2021-02) Levashova, Olga; Tishakova, TetyanaItem Biochemical Confirmation of the Anti-Inflammatory Effect of Coxibs and their Compositions with N-Acetylgulcosaminil 1-4-N-Acetylmuramoil-L-alanyl-DIsoglagamin(Letters in Applied NanoBioScience, 2021) Syrova, Ganna; Tishakova, Tetyana; Levashova, Olga; Savelieva, ОlenaItem Investigation of the Peripheral Analgesic Activity of Oxicams and Their Combinations with Caffeine(Turkish Journal of Pharmaceutical Siences, 2020-08) Syrova, Anna; Lukianova, Larysa; Kozub, Svitlana; Zavada, Oksana; Levashova, Olga; Shaposhnik, ViktorItem Psychological Aspects Of Foreign Students Adaptation(2020-01-15) Syrovaya, G.O.; Levashova, Olga; Tishakova, T.S.Item Immune histochemical study of KI-67 level and ribonucleic acid in the process of healing of burn wounds after treatment with drugs containing dexpanthenol and ceramide(2019) Butko, Yaroslava; Tkachova, Oksana; Ulanova, Vera; Müge Şahin, Yeşim; Levashova, Olga; Tishakova, TetyanaCeramides are structural components of the stratum corneum that regulate cell proliferation and differentiation. The study of the effect of the cream containing dexpanthenol and ceramide on the proliferation processes and regeneration of burn wounds in rats. Experimental rats with III-A degree thermal burn were treated separately with the following preparations: cream with ceramides, cream with dexpanthenol and ceramides and cream "Bepanten". The proliferative-regenerative activity of the drugs was investigated by studying the content of the Ki-67 producing cells and the content of ribonucleic acid (RNA) in the cytoplasm of the granulation tissue fibroblasts. Ceramides contributed to wounds healing, increasing the content of Ki-67 antigenpositive cells, accelerating the formation of scar in the wound. The therapeutic effect of creams with ceramides exceeds the efficacy of the reference preparation “Bepanten” cream. The addition of ceramides to dexpanthenol increases the quality and reduces the wound healing time.Item Research of New Effective Analgesic and Anti-inflammatory Drugs(2019-08-01) Levashova, Olga; Chalenko, Natalia; Mariutsa, Illia; Bunyatyan, NataliaItem Determination of Amino Acid Composition in the Harpagophytum procumbens Root(2019) Kriukova, Anna; Vladymyrova, I.M.; Levashova, Olga; Tishakova, Tatiyna StanislavovnaThe amino acid composition of the roots of Harpagophytum procumbens was investigated by the method of high performance liquid chromatography (HPLC) with preliminary derivatization. Sixteen free and thirteen bound amino acids were quantitatively determined. The content of protein-bound amino acids was calculated.Item Biochemical confirmation of anti-inflammatory activity of oxicam-based pharmaceutical compositions(2018-12-26) Syrova, Ganna; Tishakova, Tetyana; Levashova, Olga; Savelieva, OlenaBiochemical confirmation of anti-inflammatory activity of oxicam-based pharmaceutical compositions was performed by the determination of the level of one of the main markers of inflammation-C-reactive protein. Biochemical studies were carried out on laboratory animals (white WAG rats) to study the anti-inflammatory effects of meloxicam, piroxicam, caffeine, and pharmaceutical compositions consisting of meloxicam and caffeine, piroxicam and caffeine compared to the reference drug - sodium diclofenac. The content of CRP in serum of rats was determined using the CRP latex test kit. It was shown that the composition of meloxicam and caffeine reduced the content of CRP by 16 times compared with formalin-induced edema, and by 2 times in comparison with the reference drug diclofenac sodium, which is statistically significantly different from the control.Item Investigation Of Quantum-Chemical Properties Of Rofecoxib(2019-05) Chekman, Ivan; Syrovaya, G.; Levashova, Olga; Tishakova, T.; Kozub, Svitlana; Chalenko, Natalia