Кафедра медичної та біоорганічної хімії
Permanent URI for this communityhttps://repo.knmu.edu.ua/handle/123456789/163
Browse
52 results
Search Results
Item Creation of anti-inflammatory pharmaceutical compositions (review)(2022-11-13) Syrova, Ganna; Petyunina, Valentina; Makarov, Volodimir; Lukіаnova, Larysa; Chalenko, NataliaThe review article summarizes the data of literature and our own research on the creation of more effective and safe domestic combined drugs with a pronounced anti-inflammatory and analgesic effect. Untimely treatment of inflammatory processes often leads to long-term incapacity and even disability, so today there is an active search for new effective and safe domestic combination drugs with pronounced anti-inflammatory and analgesic effects. Due to the constant search for innovative drugs the treatment of a significant number of diseases and pathological conditions with existing drugs remains ineffective or causes addiction and a large number of side effects. As a result, inflammatory processes can be accompanied by severe pain, spasms, increased convulsive activity of the brain, other disorders, so non-narcotic analgesics and nonsteroidal anti-inflammatory drugs are combined with other agents that can cause complementary effects or potentiate each other's effects. Caffeine is a useful adjuvant of nonsteroidal anti-inflammatory drugs of various chemical structures in terms of anti-inflammatory and analgesic effects. The article presents a literature review of the current state of treatment of inflammation and pain, conducting research to expand the therapeutic capabilities of known pharmaceuticals, the creation of pharmaceutical compositions of nonsteroidal anti-inflammatory drugs with caffeine.Item Prediction of the Antiinflammatory Activity of New S-alkyl Derivatives of 1,2,4-triazol-3-thiones Using the PASS Computer Program and Molecular Docking(Borneo Journal of Pharmacy, 2020-02) Chalenko, Natalia; Syrovaya, Anna; Kobzar, Natalya; Rakhimova, Maryna; Sych, Irina; Sych, IgorItem Research of New Effective Analgesic and Anti-inflammatory Drugs(2019-08-01) Levashova, Olga; Chalenko, Natalia; Mariutsa, Illia; Bunyatyan, NataliaItem Synthesis of potential antiexudative preparations for 2-((4-amino-5-(furan-2-il)-1,2,4-triazole-(4h)-3-yl)-sulfanyl)-n-acetamide series(2019) Chalenko, Natalia; Demchenko, Anatoliy; Syrova, GannaItem Investigation Of Quantum-Chemical Properties Of Rofecoxib(2019-05) Chekman, Ivan; Syrovaya, G.; Levashova, Olga; Tishakova, T.; Kozub, Svitlana; Chalenko, NataliaItem 1,3,7-trimethylxanthine – known adjuvant of non-steroidal anti-inflammatory drugs of different chemical structures(European Academy of Science, 2018-11-30) Syrovа, Ganna; Lukianova, Larysa; Chalenko, NataliaItem The experimental research on the antiinflammatory action of the new piroxicamcaffeine pharmaceutical composition(2018) Syrova, Ganna; Lukianova, Larysa; Chalenko, NataliaConducting an experimental research on laboratory rats subjected to endogastric injections, our scientists have explored the influence of the non-steroid anti-inflamatory drug from the oxicam group piroxicam (4-hydroxo-2-methyl-N-pyridine-2-il)-2H-1,2-benzothiazine-3-carboxamide1,1- dioxyde), a well-known adjuvant of non-narcotic analgetics and non-steroid anti-inflamatory drugs such as caffeine (1,3,7-trimethylxanthine)and the two-component piroxicam-caffeine pharmaceutical composition on the rats’ anti-exudative activity under formalin edema. The analysis of the results of the experimental researches points to the fact that caffeine promotes the anti-exudative action of piroxicam in the rats under formalin edema. The above-mentioned experimental researches allow us to come to the conclusion that due to its vasoconstrictive effect caffeine performs as an adjuvant to piroxicam (a non-steroid anti-inflamatory drug from the oxicam group) concerning the anti-exudative activity. The results of the research can become a basis for the development of new combined drugs in Ukraine.Item Classification, structure and significance of biologically active heterocyclic compounds. Structure and biochemical functions of nucleosides, nucleotides and nucleic acids(ХНМУ, 2018) Syrovaya, Anna; Lukianova, Larysa; Zavada, Oksana; Petyunina, Valentina; Makarov, Volodymyr; Andreeva, Svetlana; Kozub, Svitlana; Tishakova, Tatyana; Levashova, Olga; Savelieva, Elena; Chalenko, Natalia; Kalinenko, Olga; Kopoteva, Natalia; Vodolazhenko, Mariia; Chistiakova, HalinaItem Higher fatty acids, lipids, phospholipids(ХНМУ, 2018) Syrovaya, Anna; Kozub, Svitlana; Makarov, Volodymyr; Petyunina, Valentina; Andreeva, Svetlana; Lukianova, Larysa; Tishakova, Tatyana; Levashova, Olga; Chalenko, Natalia; Savelieva, Elena; Kopoteva, Natalia; Kalinenko, Olga; Zavada, Oksana; Vodolazhenko, MariiaItem Carbohydrates: monosaccharides. Structure and functions of di- and polysaccharides(ХНМУ, 2018) Syrovaya, Anna; Petyunina, Valentina; Makarov, Volodymyr; Andreeva, Svetlana; Lukianova, Larysa; Kozub, Svitlana; Tishakova, Tatyana; Levashova, Olga; Savelieva, Elena; Chalenko, Natalia; Kalinenko, Olga; Zavada, Oksana; Kopoteva, Natalia; Vodolazhenko, Mariia; Chistiakova, Halina