Кафедра медичної та біоорганічної хімії
Permanent URI for this communityhttps://repo.knmu.edu.ua/handle/123456789/163
Browse
4 results
Search Results
Item Biochemical confirmation of anti-inflammatory activity of oxicam-based pharmaceutical compositions(2018-12-26) Syrova, Ganna; Tishakova, Tetyana; Levashova, Olga; Savelieva, OlenaBiochemical confirmation of anti-inflammatory activity of oxicam-based pharmaceutical compositions was performed by the determination of the level of one of the main markers of inflammation-C-reactive protein. Biochemical studies were carried out on laboratory animals (white WAG rats) to study the anti-inflammatory effects of meloxicam, piroxicam, caffeine, and pharmaceutical compositions consisting of meloxicam and caffeine, piroxicam and caffeine compared to the reference drug - sodium diclofenac. The content of CRP in serum of rats was determined using the CRP latex test kit. It was shown that the composition of meloxicam and caffeine reduced the content of CRP by 16 times compared with formalin-induced edema, and by 2 times in comparison with the reference drug diclofenac sodium, which is statistically significantly different from the control.Item Biochemical Confirmation of Anti-Inflammatory Activity of Oxicam-Based Pharmaceutical Compositions(2018-12-26) Syrova, Ganna; Tishakova, Tetyana; Levashova, Olga; Savelieva, OlenaBiochemical confirmation of anti-inflammatory activity of oxicam-based pharmaceutical compositions was performed by the determination of the level of one of the main markers of inflammation-C-reactive protein. Biochemical studies were carried out on laboratory animals (white WAG rats) to study the anti-inflammatory effects of meloxicam, piroxicam, caffeine, and pharmaceutical compositions consisting of meloxicam and caffeine, piroxicam and caffeine compared to the reference drug - sodium diclofenac. The content of CRP in serum of rats was determined using the CRP latex test kit. It was shown that the composition of meloxicam and caffeine reduced the content of CRP by 16 times compared with formalin-induced edema, and by 2 times in comparison with the reference drug diclofenac sodium, which is statistically significantly different from the control.Item The Synthesis of Potential Anti-Inflammatory Substances among 4-Amino-5-(Pyridin-4-yl)-1,2,4-Triazole(4н)-3-yl-Thioacetamides and their Chemical Modification(2016) Syrovaya, Anna; Chalenko, Natalia; Demchenko, AnatoliySynthesis of new 4-amino-5-(pyridin-4-yl)-1,2,4-triazole(4H)-3-ylthio-acetamides and their pyrrolyl derivatives is described in an article. The initial compound – 4-amino-3-thio-5-(pyridin-4-yl)-1,2,4-triazole(4H) were synthesized by esterification of the initial 4-pyridinecarboxylic acid, and further interaction of resulting methyl ester with hydrazide and potassium 4-pyridine dithiocarbazate wjth the following cyclisation with hydrazine hydrate. The acetamides were obtained by alkylation of the 4-amino-3-thio-5-(pyridin- 4-yl)-1,2,4-triazole(4H) with N-arylsubstituted α-chloracetamides in the presence of KOH. Using Paal-Knorr condensation, the amino group at position 4 was modified into the pyrrole fragment by the action of of 2,5-dimethoxytetrahydrofuran in acetic acid. The preliminary prediction of the possible pharmacological activity by computer prognosis (PASS software) was carried out. Due to the prognosis and analysis of logical data, the substances synthesized will be examined as possible anti-inflammatory agents.Item Creation of new drug compositions and pharmacological substantiation of their suitability for pain syndromes and inflammations in experimental rats(ХНМУ, 2014-10) Syrovaya, Anna; Bachinsky, Ruslan; Grabovetskaya, EvgeniyaCreation of combined drugs whose pharmacological effects are due to the rational combination of ingredients is the urgent problem of modern medicine. Combination of several components in one drug expands its pharmacological range and promotes polytropic activity. The advantage of combined drugs compared with pure drugs is that they more effectively eliminate pain and inflammation than each individual component. Combined analgesics often include caffeine. According to literature data caffeine enhances analgesic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) and nonnarcotic analgesics (NNA). However, there are no data on the composition of diclofenac sodium (D-Na), ibuprofen (Ib) with caffeine in the literature. This fact caused experimental studies of influence of caffeine on the analgesic and anti-exudative effects of D-Na and Ib. Experimental studies have been conducted on laboratory animals (white adult rats of the WAG strain) by intragastric administration. Analysis of experimental results clearly indicates that caffeine potentiates analgesic and anti-exudative effects of D-Na and Ib. Thus, compositions of D-Na and Ib with caffeine were experimentally studied for the first time. Suitability of compositions is proved and application in inflammation and pain of various origins is demonstrated. Results can serve as foundation for development of new domestic combined drugs with analgesic and anti-inflammatory effects.