Кафедра медичної та біоорганічної хімії

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    Experimental substantiation for new medicinal compositions design
    (ORT Publishing, 2016) Syrovaya, Anna; Grabovetskaya, Evgeniya
    Analgesic and antiexudative activities of paracetamol and carbamazepine combinations with caffeine are examined in the experiment on laboratory rats. It is shown that caffeine potentiates antiexudative and analgesic activities of paracetamol and carbamazepine. The composition of paracetamol with caffeine is found to be the most effective among all investigated compounds.
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    Experimental study of caffeine influence on antiexudative activity of known NSAIDs of different chemical structure
    (2015-09) Syrovaya, Anna; Grabovetskaya, Evgeniya
    Antiexudative activity of combinations of some anti-inflammatory drugs with caffeine is shown in the experiment. It is found that caffeine potentiates antiexudative activity of diclofenac sodium, ibuprofen and paracetamol. It is discovered that the composition of caffeine with ibuprofen has more intensive antiexudative effect than the composition of caffeine with diclofenac sodium and paracetamol.
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    Investigation of quantum-chemical properties of paracetamol
    (Iaipur, India, 2015) Syrovaya, Anna; Levashova, Olga; Andreeva, Svetlana
    Paracetamol is a widely used drug in medical practice. We have studied the quantum-chemical properties of paracetamol,which are vital for understanding of mechanisms of biological and pharmacological activity at a molecular level. The geometry optimization for paracetamol molecule was performed by PM3 method, PolakRibiere algorithm. We have determined the distance between atoms, total charge density, characteristics of molecular orbitals (HOMO, LUMO) of paracetamol molecule.