Кафедра медичної та біоорганічної хімії
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Item Healing Features of Pomegranate(НФаУ, 2020-04-03) Kopoteva, Natalia; Kalinenko, Olga; Krasnikova, YuliyaItem Experimental investigation of the effect of pharmaceutical composition on the central nervous system(KhNMU, 2019) Syrova, Ganna; Lukianova, Larysa; Sinelnik, Vyacheslav; Krasnikova, Yuliya; Salam, LoginaIt is known that combination of non-steroidal anti-inflammatory drugs with other drugs can cause complementary effects, or potentiate the effects of each other. Object and methods. The objective of this experiment is to analyze the use of a new pharmaceutical composition consisting of nonsteroidal anti-inflammatory drug of the coxib group (rofecoxib) and an immunomodulator of lycopid (glucosaminylmuramyl dipeptide). An experiment on laboratory animals was conducted in order to view the effect of rofecoxib, licopid and their pharmacological composition on the central nervous system and on emotional-behavioral reactions in an "open field" test under formalin edema conditions. Results Previously, we studied the pharmaceutical compositions of nonsteroidal anti-inflammatory drugs of different chemical structure with the psychostimulant caffeine. The results indicated that caffeine potentiated the pharmacological effects of nonsteroidal anti-inflammatory drugs. In this study, we set a goal to create a pharmaceutical composition of rofecoxib with licopid and investigated its effect on the emotional-behavioral reactions of rats under formalin edema conditions. Ànalysis of the experimental results show that the addition of licopid to rofecoxib contributed to an increase in rat's locomotor and orienting-research activities and also an increase in the indicators of their emotional reactions (urination and defecation) compared to the mono-administration of rofecoxib. Conclusions. The pharmaceutical composition of rofecoxib and licopid is expedient and promising for the study of anti-inflammatory and analgesic effects.Item Experimental investigation of the influence of pharmaceutical composition on emotional behavioral reactions under conditions of formalin edema(Cognum Publishing House, Liverpool, United Kingdom, 2019-10-09) Syrova, Ganna; Lukianova, Larysa; Krasnikova, Yuliya; Sinelnik, VyacheslavThe analysis of the results of experimental studies of the effect of celecoxib, licopid and their pharmaceutical composition on the central nervous system by emotional-behavioral reactions in the test "open field" in the conditions of formalin edema indicates that the addition of licopid to celecoxib increased rat’s locomotor and orienting-research activities, the indicators of their emotional reactions (washings and urinations) in comparison with the mono-administration of celecoxib. The pharmaceutical composition of celecoxib and licopid is appropriate and promising for the study of anti-inflammatory and analgesic effects.Item How meloxicam, caffeine and their pharmacological composition influence the emotional-behavioral reactions in rats under formalin edema(2017-06-15) Lukianova, Larysa; Syrovayа, Anna; Andreeva, Svetlana; Krasnikova, Yuliya; Issaaka, AdamuItem Infuence of caffeine on analgesic activity of мeloxicam in the condition of formalin edema(НМАПО ім. П.Л. Шупика, 2017-05-18) Matrunich, Dmitro; Kolesnyk, Maria; Chalenko, Natalia; Lukianova, Larysa; Krasnikova, Yuliya; Sinelnik, VyacheslavItem The influense of caffeine on antiexudative activity of meloxicam under the conditions of formalin-inducend edema(Минск, БГМУ, 2017) Kolesnyk, Maria; Chalenko, Natalia; Lukianova, Larysa; Krasnikova, Yuliya