Наукові праці. Кафедра інфекційних хвороб

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2012 - 20188

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Author: search.filters.author.Kozko, VolodymyrSubject: search.filters.subject.chronic hepatitis C

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Now showing 1 - 8 of 8
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    Application of apri index for noninvasive evalution of liver fibrosis activity in patients with chronic hepatitis C
    (2018-04-24) Kozko, Volodymyr; Vinokurova, O.; Baichykova, A.; Pavlova, A.
    seventy-nine patients, age from forty to forty-five years old, with chronic hepatitis C were examined in the clinic. All the patients studied determined the stage o f fibrosis and the severity o f the disease with the help o f the GenoFibroTest system, an expert system o f biochemical blood indices. Modern statistical methods were used to determine the dependence between the stages o f fibrosis and APRI. It was found that the APRI value from 0 to 1 corresponds to F0 - F1, more than 1 to F2-F4, respectively.
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    The role of polymorphism ASP299GLY of the gene TLR 4 in patients co-infected with HIV/HCV
    (Tbilisi State Medical University, 2018-07) Yurko, K.; Kozko, Volodymyr; Solomennik, A.; Bondar, O.; Sokhan, A.; Gavrylov, Anatoliy
    For the first time it was conducted complex research of metabolic disorders in patients co-infected with HIV/HCV and was shown that they are characterized by disturbances of mineral, lipid and carbohydrate metabolism types. It was established significantly higher values of indicators of mineral, lipid and carbohydrate metabolism types in patients co-infected with HIV/HCV compared with patients with chronic hepatitis C and HIV-infected persons. In patients co-infected HIV/HCV appears significantly more frequent the polymorphism Asp299Gly of the gene TLR4 (χ2 = 4,5; p<0,05) when compared with healthy donors, which plays a significant role in the development of metabolic disorders, such correlation is confirmed by those relationships: a strong direct relationship between the polymorphism Asp299Gly of TLR4 gene and the content of insulin (r = 0,66; p<0,001), insulin resistance (r=0,66; p<0,001), the absolute number of CD45+ of T-lymphocytes (r=0 45; p<0,001); a moderate direct relationship with the content of TNF-α (r=0,32; p<0,05), CRP (r=0,34; p<0,05), the absolute number of CD3+ of T-lymphocytes (r=0,34; p<0,05), the content of triglyceride (r=0,39; p<0,02), moderate inverse relationship with the zinc content (r = -0,34; p<0,05 ), the relative number of CD4 +,% (r = -0,32; p<0,05). The system of monitoring of metabolic disorders in patients co-infected with HIV/HCV based on the definition of polymorphism Asp299Gly gene TLR4, the presence of which indicates a high risk of metabolic disturbances (OR=23,3; p<0,05) and requires further investigation, namely the definition of an index of insulin resistance, insulin levels, TNF-α, C-reactive protein, zinc and triglyceride levels in dynamics at intervals of 6 months that allow for timely diagnosis and correction of metabolic disorders.
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    Hematologikal disorders in patients with chronic hepatitis C during antiviral therapy
    (2015-03-30) Kozko, Volodymyr; Bondar, O.; Solomennik, A.; Sokhan, A.; Ancyferova, N.; Penkov, D.; Katelevskaya, V.
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    Features of lipid metabolism disorders in patients co-infected with HIV/HCV
    (2015) Kozko, Volodymyr; Iurko, Kateryna; Adeyemi, A.
    The content of lipid metabolism was determined in 107 patients: with chronic hepatitis C - 36 patients, with HIV infection - 35 and co-infection of HIV/HCV – 36 patients. In the investigated patients lipid metabolism disorders were identified such as an increase of the triglycerides, low density lipoprotein, very low density lipoprotein and a reduction of high density lipoprotein contents. Significantly higher levels of triglycerides (p<0.001) was observed in patients co-infected with HIV/HCV compared with patients with chronic hepatitis C and HIV-infection.Systematic data analysis suggests that in patients co-infected with HIV/HCV established a strong direct relationship between the level of CD4+ cells and the degree of increase in triglycerides (r=0,64, p<0.001), atherogenic coefficient (r=0,57, p<0.001).
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    Predicting the effectiveness of antiviral therapy in patients with chronic hepatitis c genotype 1
    (2014-03) Bondar, O.; Kozko, Volodymyr; Solomennik, A.; Sokhan, A.
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    Effectiveness of the drug phosphogliv in patients with chronic hepatitis C
    (2014-03) Kozko, Volodymyr; Solomennik, G.; Bondar, O.; Mohylenets, Olena; Merkulova, Nina; Vinokurova, O.; Iurko, Kateryna; Minakova, S.
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    Frequency of hematologic disorders in patients with chronic hepatitis C receiving antiviral therapy
    (2014-03) Bondar, O.; Kozko, Volodymyr; Solomennik, A.; Sokhan, A.
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    Metabolic indexes state studing in patients with chronic viral hepatitis C
    (2012) Kozko, Volodymyr; Zhukov, V.; Grannatyuk, S.; Mozgova, Y.
    Endogen intoxication trigger in acute hepatitis C is hepatic cells cytolysis caused by viral reproduction with subsequent immune system reaction. All above mentioned needs further study of formation mechanisms in chronic hepatitis C(CHC) and motivation of immunosuppressive therapy.