Наукові роботи молодих вчених. Кафедра внутрішньої медицини № 3 та ендокринології
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Item Ways to optimize the treatment of biliary system disorders in patients with type 2 diabetes(2020) Tymoshenko, GalynaThe aim is to evaluate the effectiveness of complex therapy involving ursodeoxycholic acid and α-lipoic acid in patients with a combination of type 2 diabetes mellitus and chronic noncalculous cholecystitis based on the study of the dynamics of cholecystosonography parameters (in examination and the dynamic variants).Item Significance of metabolic parameters in patients with type 2 diabetes mellitus and chronic pancreatitis in forecasting the level of vaspin(2020) Pylov, DanielAdipokines are closely associated with the development of diseases and conditions such as type 2 diabetes mellitus, dyslipidemia, hypertension, atherosclerosis and inflammation, as they contribute to the development of insulin resistance, metabolic disorders, stimulate local inflammation and may affect atherogenesis process. Vaspin, a new serine protease inhibitor produced by visceral adipose tissue is an adipokine with insulin-sensitive and anti-inflammatory properties and has angio- and cardioprotective effects.Item Relationship between sleep status and the type 2 diabetes course(2020) Baskakova, Anastasiia; Sikalo, YuliiaType 2 diabetes mellitus is a current disease and a priority problem of the global health care system, given the steady growth of its prevalence. Since 2016, more than 2 million patients with DMhave registered in Ukraine, 90% are patients with type 2 diabetes mellitus. According to a report by the World Health Organization, type 2 diabetes mellitus is one of the four priority noncommunicable diseases included in the Global Action Plan for the Prevention and Control. At the present stage, the algorithm for combating type 2 diabetes mellitus involves, above all, early diagnosis and detection of relatively healthy population risk factors, their correction, as well as dynamic control of carbohydrate metabolism.Item Effect of lyraglutide on the lipid profile in patients with type 2 diabetes(2020) Amarachi, Adaeze Uzoma; Sokolnikova, NeliaType 2 diabetes mellitus is a complex metabolic disorder which characterized be carbohydrate, protein and lipid metabolism disorder due to target tissue resistance to insulin and its cellular metabolic effect. Obesity-dependent diabetes can significantly decrease life expectance. Diabetes mellitus type 2 accounts for about 90% to 95% of cases and the recent explosion of diabetes has aggravated insulin resistance and contributed greatly to the diabetes epidemic. Excess fat causes cells to be less responsive to insulin. In obese individuals, adipose tissue secretes excess of non-esterified fatty acids and other substances that affect metabolism such as glycerol, hormones, proinflammatory cytokines, leptin and others.Item Effect of Interleukin Beta and Resistin on Development of Cardiomyopathy in Type 2 Diabetes(2020) Zhuravlyova, Larysa; Sokolnikova, Nelia; Mohammed, KassimType 2 diabetes occurs when our body becomes resistant to insulin and pancreas produce more insulin to compensate and later pancreas becomes decompensated.Type 2 diabetes is major risk factor for cardiovascular disease.Item The vitamin D in patients with osteoarthritis and type 2 diabetes mellitus(2020) Magapu, Veera Venkata AkhilThe aim of the study is to determine the level of vitamin D in patients with osteoarthritis and with the combination of osteoarthritis and type 2 diabetes mellitus and its effect on the course of type 2 diabetes mellitus and osteoarthritis.Item Співвідношення інсуліноподібного фактора росту-1 та показників стану вуглеводного обміну у хворих з поєднаним перебігом артеріальної гіпертензії та цукрового діабету типу 2(2017) Пивоваров, Олександр Васильович; Журавльова, Лариса ВолодимирівнаПроведено оцінку ролі соматомедину інсуліноподібного фактора росту-1 у прогнозуванні розвитку цукрового діабету (ЦД) типу 2. Встановлено кореляційні взаємозв’язки між рівнем соматомедину інсуліноподібного фактора росту-1 у крові та показниками стану вуглеводного обміну. Найвищий середній рівень інсуліноподібного фактора росту-1 у крові спостерігали серед хворих з поєднаним перебігом артеріальної гіпертензії (АГ) та ЦД типу 2. У всіх групах виявлено прямий кореляційний зв’язок між рівнем інсуліноподібного фактора росту-1 у крові та величиною індексу НОМА-ІR. Найвище значення коефіцієнта кореляції було у хворих з поєднаним перебігом АГ та ЦД типу 2. Проведена оценка роли соматомедина инсулиноподобного фактора роста-1 (ИФР-1) в прогнозировании развития сахарного диабета (СД) типа 2. Установлены корреляционные взаимосвязи между уровнем соматомедина ИФР-1 в крови и показателями состояния углеводного обмена. Самый высокий средний уровень ИФР-1 в крови наблюдали среди больных с сочетанным течением артериальной гипертензии (АГ) и СД типа 2. Во всех выделенных группах отмечена прямая корреляционная связь между уровнем ИФР-1 в крови и величиной индекса НОМА-ІR. Наивысшее значение коэффициента корреляции оказалось во ІІ группе больных с сочетанным течением АГ и СД типа 2.An assessment of the role somatomedin insulin-like growth factor-1 in the prediction of diabetes mellitus type 2. The presence of correlation relationships between levels of somatomedin insulin-like growth factor-1 in blood and indicators of carbohydrate metabolism. The highest average levels of insulin-like growth factor-1 in blood was observed among patients with combined flow of arterial hypertension and diabetes mellitus type 2. All selected groups there was a direct correlation between the level of insulin-like growth factor-1 in blood and value of HOMA-IR index. The highest correlation coefficient was in the second group of patients with combined flow of arterial hypertension and diabetes mellitus type 2.Item Changes of lipid profile in patients with chronic pancreatitis and diabetes mellitus type 2(2014) Shekhovtsova, YuliiaThe aim of the present study was to investigate changes of lipid profile in patients with combined course of CP and DM2.Item The influence of tumor necrosis factor-α on processes of citolisis and cholestasis in patients with comorbid pathology(2013) Ogneva, OlenaTumor necrosis factor-α (TNF-α) is an adipokine that can cause the cytotoxic effects and can stimulate the apoptosis, impairing liver function. There is a need in further study of TNF-α influence on liver cells properties and its role in the pathogenesis of nonalcoholic fatty liver disease against the background of diabetes mellitus type 2 and obesity.Item Relationship leptin and body mass index in patients with diabetes mellitus type 2(2012) Sokolnikova, NeliaOverweight plays an important role in the development of cardiovascular complications in patients with diabetes mellitus type 2 (DM-2). The risk of acute complications (myocardial infarction, stroke) increases along with the body weight gain. Leptin is a hormone produced by adipose tissue. Experimental and clinical studies indicate various negative effects of leptin and leptin resistance