Наукові роботи молодих вчених. Кафедра внутрішньої медицини № 3 та ендокринології
Permanent URI for this collectionhttps://repo.knmu.edu.ua/handle/123456789/873
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Item A systematic review of dapagliflozin treatment for patients with type 2 diabetes mellitus(2017) El-Hayek, MohamadNew class of drugs for treatment type 2 diabetes mellitus (T2DM) are sodium-glucose cotransporter 2 (SGLT2) inhibitors. These drug are an antihyperglycaemic agents with an insulin-independent mode of action. One of the SGLT2 inhibitors class that used in Ukraine for treatment patients with T2DM is a Dapagliflozin. We try to summarize current evidence from different clinical trials that assess the clinical efficacy and safety of dapagliflozin.Item ANTI-VEGF терапія(2024) Кайсина, Софія Михайлівна; Рогачова, Тетяна АндріївнаДіабетична ретинопатія (ДР) залишається одним з ускладнень цукрового діабету (ЦД) та вагомішою причиною втрати зору в осіб працездатного віку. Механізм розвитку ДР багатофакторний й включає порушення усіх ланок метаболізму речовин: вуглеводного, білкового, ліпідного та мінерального.В даний час препарати проти VEGF, які використовуються в клініці та в дослідженнях поділяються на препарати, які блокують зв’язування VEGF і препарати, які пригнічують експресію гена VEGF. Блокуючи активацію VEGF, моноклональні антитіла можуть зменшити підвищення проникності судин, викликане підвищенням VEGF, пригнічувати ріст новоутворених судин і покращувати гостроту зору пацієнтів.Item Biological therapy in patients with Rheumatoid arthritis(2015) Исаак, Адора; Дуглас, Ибиба; Isaak, A.; Duglas, I.The foundation of modern biological therapy have significantly changed the whole system of treatment of rheumatic diseases, is the use of antagonists of tumor necrosis factor alpha (TNF-α). Drugs of this class are most relevant concepts of "disease-control" means, as to significantly reduce the direct manifestation of the disease and significantly inhibit joint destruction, leading to the development of disease remission with previously unattainable speed.Item Changes of lipid profile in patients with chronic pancreatitis and diabetes mellitus type 2(2014) Shekhovtsova, YuliiaThe aim of the present study was to investigate changes of lipid profile in patients with combined course of CP and DM2.Publication A clinical case of extraintestinal manifestations of ulcerative colitis(2023) Satapathy, Ayusha; Oliinyk, MariiaThe problem of treatment of inflammatory bowel diseases is relevant today. According to the International Research Committee, the incidence of ulcerative colitis (UC) has been steadily increasing in all countries in recent years. Arthritis develops in 20% of UC patients and is characterized by the involvement of a small number of large joints. Changes in the joints are usually completely reversible, but relapses are possible, the occurrence of which can be associated with an exacerbation of the underlying disease.Item Clinical case of paraneoplastic syndrome(2018) Piatygor, AnastasiiaAim. Studying of the clinical course of secondary (paraneoplastic) dermatomyositis, (DM) as manifestation of cervical cancer.Publication A clinical case of Schmidt syndrome(2023) Oliinyk, Mariia; Okhaigbe, Daniel OshokeSchmidt syndrome [also known as autoimmune polyendocrine syndrome type 2 (APS-2) is a term used to refer to a number of autoimmune disorders (primary adrenal insufficiency, hypothyroidism and type 1 diabetes mellitus) as a whole rather than a single illness.Item Clinical case of the myocardial infarction in young woman(2018) Likha, Victorija; Dontsova, ElizavetaMyocardial infarction (MI) is the extreme degree of coronary heart disease (CHD), which is characterized by the presence of a section of myocardial necrosis, through complete or relative insufficiency of blood supply in this area. In the general structure of mortality, cardiovascular diseases in Ukraine in 2017 occupy 62%, most of them with MI. At the same time, the mortality rate from acute infarction in developed countries does not exceed 5%. The main etiological factors coincide with the risk factors of atherosclerosis: diabetes, hypercholesterolemia, high blood pressure, smoking, the presence of ischemic heart disease in family anamnesis, obesity (defined if BMI (body mass index) is more than 30 kg / m2), age (for men - risk factor after 45 years, for women - after 55 years). Aim. Description the clinical case of a MI without a Q-wave at a young patient.Item Clinical case review on idiopathic pulmonary fibrosis(2020) Hossam, Bajbouj; Alkassab, Lila; Yankevych, OleksandrThe study covered a 62 years old female patient. The patient suffered from fatigue, dry cough, shortness of breath with moderate exercise, and intermittent discomfort in the heart. She had a history of recurrent pneumonia for 3 years that was later on treated and increased BP to a maximum of 160/90 mmHg. An angiogram and a high-resolution computed tomography (HRCT) of the lungs were conducted.Item Correlation between body mass index and indices of diastolic function in patients with type 2 diabetes mellitus(2013) Sokolnikova, Nelia; Rashad, SalamehType 2 Diabetes mellitus (DM2) is a proven risk factor for development of metabolic cardiomyopathy. The majority of patients with DM2 have an elevated body mass index which is a risk factor for development of cardiovascular diseases. However, the relationship between the development of diabetic cardiomyopathy as a primary myocardial injury in DM2 and an elevated body mass index in patients with DM2 has not been yet thoroughly studiedItem Determination of the prevalence of helicobacter pylori infections among medical students on the background of measuring metabolic indicators(2019) Stoyan, AnnaIn the modern world, infection with Helicobacter pylori is the most common bacterial cause of gastroenteritis. Helicobacter pylori infection is a long-standing, but still an urgent problem of elderly people with the possible addition of oncological and cadiological pathologies. The aim of our work: assess the prevalence of Helicobacter pylori in medical students due to metabolic parameters and dietary habits.Item Development of type I diabetes mellitus induced by nonalcoholic fatty liver disease(2019) Gorbunova, Alesia; Lakhno, OlhaDiabetes Mellitus is one of the most common diseases and poses a global problem, which spreads from year to year. According to statistic, globally 371 million people suffer from this disease, which corresponds to 7% of the total population of the Earth. Prevalence of DM and its consequences such as complications and associated diseases present the biggest challenge to the global healthcare, and according to the International Diabetes Federation it is primarily related to the fact that about 46% of the patients are unaware of their illness.Item Diagnostic essays of clinical masks of autoimmune hepatitis(2019) Markevych, Mykyta; Stoianova, YuliiaThe prevalence of autoimmune diseases increases among population during last years. Several studies show that combined autoimmune pathology is the most typical for autoimmune hepatitis. Therefore, the aim of our research was to study the frequency of combination of autoimmune hepatitis with other autoimmune diseases.Item Difficulty of optimal therapy selection in the case of polymorbid patient(2018) Chirva, AnnaObjective: studying the selection of correct diagnosis and the choice of therapy in patients with polymorbid condition.Item Effect of additional antioxidant therapy in patients with combine course of osteoarthritis and type 2 diabetes mellitus(2018) Nagiyeva, Aynur; Rybina, AnastasiiaThe aim of the present study to learn the influence of antioxidant therapy on the condition of patients with osteoarthritis (OA) in combination with type 2 diabetes mellitus (T2DM).Item Effect of Interleukin Beta and Resistin on Development of Cardiomyopathy in Type 2 Diabetes(2020) Zhuravlyova, Larysa; Sokolnikova, Nelia; Mohammed, KassimType 2 diabetes occurs when our body becomes resistant to insulin and pancreas produce more insulin to compensate and later pancreas becomes decompensated.Type 2 diabetes is major risk factor for cardiovascular disease.Item Effect of lyraglutide on the lipid profile in patients with type 2 diabetes(2020) Amarachi, Adaeze Uzoma; Sokolnikova, NeliaType 2 diabetes mellitus is a complex metabolic disorder which characterized be carbohydrate, protein and lipid metabolism disorder due to target tissue resistance to insulin and its cellular metabolic effect. Obesity-dependent diabetes can significantly decrease life expectance. Diabetes mellitus type 2 accounts for about 90% to 95% of cases and the recent explosion of diabetes has aggravated insulin resistance and contributed greatly to the diabetes epidemic. Excess fat causes cells to be less responsive to insulin. In obese individuals, adipose tissue secretes excess of non-esterified fatty acids and other substances that affect metabolism such as glycerol, hormones, proinflammatory cytokines, leptin and others.Item Evaluating of tnf-α blocker therapy adherence in patients with psoriatic arthritis and psoriasis(2018) Kolotilov, Oleksii; Tyrkin, Dmytro; Sikalo, YuliiaAim: Evaluating of efficiency and adherence of therapy with TNF-α blocker infliximab in patients with psoriatic arthritis (PsA) and psoriasis (Ps).Item Evaluation of insulin pump therapy effectiveness in case of 1st type diabetes mellitus(2018) Pischik, Anastasiia; Pasechnik, SofiyaObjective: to evaluate the effectiveness of using an insulin pump (IP) in patients with type 1 diabetes mellitus (T1DM).Item Features of infective endocarditis in ingecting drug addicts on clinical example(2018) Koliubaieva, OlenaThe incidence of infectious endocarditis (IE) among injecting drug addicts (IDAs) is 5-10% per year, which is significantly higher than the incidence rate in the general population. It was found that in 75-80% of cases IE develops on the right side in IDAs, in comparison with 9% in nonaddicts, and in 40-70% of cases the tricuspid valve is affected. The course of the disease has atypical manifestations, so untimely diagnosis and treatment of IE often leads to the development of multi-organ failure. Young age of patients and high lethality (40-60%) make the problem of IE in addicts not only medical, but also social. Aim: to study the features of the clinical course, diagnosis and treatment of IE in a patient with intravenous drug use.