Type 2 diabetes mellitus is a complex metabolic disorder which characterized be carbohydrate, protein and lipid metabolism disorder due to target tissue resistance to insulin and its cellular metabolic effect. Obesity-dependent diabetes can significantly decrease life expectance. Diabetes mellitus type 2 accounts for about 90% to 95% of cases and the recent explosion of diabetes has aggravated insulin resistance and contributed greatly to the diabetes epidemic. Excess fat causes cells to be less responsive to insulin. In obese individuals, adipose tissue secretes excess of non-esterified fatty acids and other substances that affect metabolism such as glycerol, hormones, proinflammatory cytokines, leptin and others.
