Depressive disorders in patients with mitochondrial pathology (mechanisms of formation, clinical typology, system of correction and prevention)

Abstract

This research introduce a modern understanding of the functioning of mitochondria, the flow of the main biochemical processes that are related to energy metabolism. A generalized characteristic of the mitochondrial genome mutations and types of mitochondrial dysfunctions are presented. The modern ideas about the occurrence of mental disorders in patients with mitochondrial pathology are analyzed.

In order to study depressive disorders, 171 patients with mitochondrial pathology were examined both sex, ages range 18 to 57 During the data examination the most common clinical and psychopathological features of the examined patients with MP, The most common complication of MP was depressive statement. An additional analysis of depressive disorders and their variants are carried out.

The were screened 26 families of patients with mitochondrial pathology, including 14 families of patients with MP, which were accompanied by depressive disorders and 12 families of patients with MP without affective disorders. The large frequency of psychosomatic symptoms and depression weredetected by mother’s side relative probands.

According to the results of the study, patients received pharmaco-and psychotherapy care, depending on the clinical manifestations of depressive symptoms and the degree of their severity. Psycho-educational work was conducted with patients and their families.