Experimental investigation of the effect of pharmaceutical composition on the central nervous system

dc.contributor.authorSyrova, Ganna
dc.contributor.authorLukianova, Larysa
dc.contributor.authorSinelnik, Vyacheslav
dc.contributor.authorKrasnikova, Yuliya
dc.contributor.authorSalam, Logina
dc.date.accessioned2019-11-06T08:07:02Z
dc.date.available2019-11-06T08:07:02Z
dc.date.issued2019
dc.description.abstractIt is known that combination of non-steroidal anti-inflammatory drugs with other drugs can cause complementary effects, or potentiate the effects of each other. Object and methods. The objective of this experiment is to analyze the use of a new pharmaceutical composition consisting of nonsteroidal anti-inflammatory drug of the coxib group (rofecoxib) and an immunomodulator of lycopid (glucosaminylmuramyl dipeptide). An experiment on laboratory animals was conducted in order to view the effect of rofecoxib, licopid and their pharmacological composition on the central nervous system and on emotional-behavioral reactions in an "open field" test under formalin edema conditions. Results Previously, we studied the pharmaceutical compositions of nonsteroidal anti-inflammatory drugs of different chemical structure with the psychostimulant caffeine. The results indicated that caffeine potentiated the pharmacological effects of nonsteroidal anti-inflammatory drugs. In this study, we set a goal to create a pharmaceutical composition of rofecoxib with licopid and investigated its effect on the emotional-behavioral reactions of rats under formalin edema conditions. Ànalysis of the experimental results show that the addition of licopid to rofecoxib contributed to an increase in rat's locomotor and orienting-research activities and also an increase in the indicators of their emotional reactions (urination and defecation) compared to the mono-administration of rofecoxib. Conclusions. The pharmaceutical composition of rofecoxib and licopid is expedient and promising for the study of anti-inflammatory and analgesic effects.ru_RU
dc.identifier.citationExperimental investigation of the effect of pharmaceutical composition on the central nervous system / G. Syrova, L. Lukianova, V. Sinelnik, Yu. Krasnikova, Logina Salam // Inter collegas : theoretical & experimental medicine. – 2019. – Vol. 6, № 3. – P. 162–167.ru_RU
dc.identifier.urihttps://repo.knmu.edu.ua/handle/123456789/24437
dc.language.isoenru_RU
dc.publisherKhNMUru_RU
dc.subject"open field"ru_RU
dc.subjectlicopidru_RU
dc.subjectrofecoxibru_RU
dc.subjectpharmaceutical compositionru_RU
dc.subjectformalin edemaru_RU
dc.titleExperimental investigation of the effect of pharmaceutical composition on the central nervous systemru_RU
dc.typeArticleru_RU

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