Кафедра інфекційних хвороб, дитячих інфекційних хвороб, фтизіатрії та пульмонології
Permanent URI for this communityhttps://repo.knmu.edu.ua/handle/123456789/31705
Browse
4 results
Search Results
Item Clinical and laboratory characteristics of patients with coronavirus infection covid-19 and its comorbidity(Клінічна та профілактична медицина, 2024) Andrusovych, Inna; Yurko, KaterynaThe coronavirus disease has reached an alarming epidemic scale with extraordinary morbidity and mortality rates for the entire world population. The majority of patients with COVID-19 note damage to the respiratory tract and state a more severe course of the disease with the development of systemic damage. A more severe course of COVID-19 is associated with the presence of comorbid diseases.Item Psychological features of the rehabilitation of persons in post-COVID-19 condition(Georgian Association of Business Press, 2024) Bondarenko, A.; Malieieva, O.; Malieiev, D.; Lantukh, I.; Filonenko, O.; Baiazitov, D.; Gulbs, O.The global medical problem has become the COVID-19 pandemic since 2019, which represents one of the most difficult medical realities. One of the crucial medical hypotheses is the effect of SARS-Cov-2 infection on mental health that requires creation of effective psychological and psychiatric management of such patients. In connection with described above, we set the task of our research to develop and test a complex of psychological interventions in the system of psychosocial rehabilitation of patients with cognitive disorders against the background of the endured SARS-Cov-2 infection. Materials and methods: The material of the study was the data obtained after passing the GAD-7 test for level of anxiety detection. The persons were divided into two groups with patients who have a history of severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2) and non-suffered with coronavirus. At the end of the course of psychological rehabilitation, the GAD-7 test was repeated. Results: It was established that people who have endured COVID-19 have a significantly higher level of anxiety during examining the initial level of anxiety by performing the GAD-7 test. So, if most of the examined had a minimal level of anxiety (68%) in the control group, then after COVID-19 the majority of patients had a moderate level of anxiety (64%), and 6% even had a high level of anxiety. A month after the initial testing, the group of patients (after COVID-19) who had not undergone psychological rehabilitation was still predominantly in the zone of moderate level of anxiety (54%). Going through psychological rehabilitation had positive consequences and the majority of patients moved into the minimal level of anxiety zone (58%). Conclusions: Majority of persons who endured COVID-19 suffer moderate level of anxiety with GAD-7 test 10.12±0.43 (6.92±0.33 for non-suffered). Psychological rehabilitation could reduce it to 7.24±0.36. The data obtained in the course of the work testify to the effectiveness of conducting a complex of psychotherapeutic interventions using cognitive training, cognitive-behavioral psychotherapy in the system of psychosocial rehabilitation of patients with cognitive disorders against the background of COVID-19 with reducing level of anxiety. Results provide critical information on the efficacy of psychological rehabilitation for persons who experience persistent cognitive deficits after COVID-19.Item Clinical and laboratory charecteristics of patients with coronavirus infection COVID-19 and its comorbidity(Державна наукова установа «Центр інноваційних технологій охорони здоров’я» Державного управління справами, 2024) Yurko, Kateryna; Andrusovych, InnaIntroduction. The coronavirus disease has reached an alarming epidemic scale with extraordinary morbidity and mortality rates for the entire world population. The majority of patients with COVID-19 note damage to the respiratory tract and state a more severe course of the disease with the development of systemic damage. A more severe course of COVID-19 is associated with the presence of comorbid diseases. Aim. To investigate and analyze clinical and laboratory manifestations and to determine the main comorbidities of patients with COVID-19 infection. Materials and methods. The research was carried out in accordance with bioethical norms and rules. 179 patients with COVID-19 (the main group) and 42 people of the control group were examined. Diagnosis and treatment of the COVID-19 coronavirus infection was carried out taking into account the relevant national recommendations. The average value and standard deviation were statistically determined. The probability of differences was performed using the Mann- Whitney U-test and the Wilcoxon W-test of signed ranks. The threshold value of the level of statistical significance of all calculated features was taken as 0.05 (p=0.05). Results. A high comorbidity with cardiovascular system pathology was found–40.2 %, type 2 diabetes–22.3 %, respiratory system diseases–20.7 %. Disorders of the functional state of the cardiovascular system were determined: pulse values–91.01±13.44, systolic (127.9±15.19) and diastolic (79.3±11.6) blood pressure. Changes in clinical blood analysis were noted: erythrocytes–4.38±0.65 x1012/l, hemoglobin–127.6±21.2 g/l, hematocrit–0.37±0.07, leukocytes–10.7±7, 32 x109/l, segmented (65.4±14.8 %) and rod-nuclear (9.03±9.99 %) neutrophils, platelets–226.1±90.6 x109/l, lymphocytes–20.24±12.43 %, monocytes–6.60±4.37 % and erythrocyte sedimentation rate (ESR)–25.4±14.9 mm/h. Significant (almost fourfold) increases in IL-6 levels (24.56±22.9 pg/ml) and blood glucose concentrations (7.40±3.42 mmol/l) were determined. Conclusions. A significant comorbidity of COVID-19 was determined and a significant prevalence of indicators of the functional state of the cardiovascular system and a decrease in the average levels of the quantitative composition of erythrocytes and indicators of hemoglobin and hematocrit were established. Significant leukocytosis, neutrophilia, lymphocytosis and monocytosis, significant excesses of ESR and IL-6 and blood serum glucose were determined, which confirmed the presence of a significant inflammatory reaction in response to infection with COVID-19.Item Treatment outcomes and risk factors for an unsuccessful outcome among patients with highly drug-resistant tuberculosis in Ukraine(Elsevier B.V., 2024) Pedersen, Ole Skouvig; Butova, Tetiana; Kapustnyk, Valeriy; Miasoiedov, Valerii; Kuzhko, Mykhailo; Hryshchuk, Leonid; Kornaha, Svitlana; Borovok, Natalia; Raznatovska, Olena; Fedorec, Andrii; Bogomolov, Artemii; Tkhorovskiy, Mykhaylo; Akymenko, Oleksandra; Klymenko, Iurii; Kulykova, Olena; Karpenko, Zhanna; Shapoval, Tetiana; Chursina, Nataliia; Kondratyuk, Natalia; Parkhomenko, Olha; Sazonenko, Inna; Ostrovskyy, Mykola; Makoida, Iryna; Markovtsiy, Lyubov; Skryp, Vasyl; Lubenko, Victoriya; Hrankina, Nataliia; Bondarenko, Leonid; Hlynenko, Valentyna; Dahl, Victor Næstholt; Butov, DmytroObjectives: To describe demographics, clinical features, and treatment outcomes of patients with highly drug-resistant tuberculosis (TB) in Ukraine, and to evaluate risk factors for an unsuccessful outcome. Methods: Data from patients with multi-, pre-extensively, or extensively drug-resistant TB were collected prospectively from TB dispensaries in 15 out of 24 Ukrainian oblasts (regions) from 2020 to 2021. Treatment outcomes were evaluated using WHO definitions. Risk factors for an unsuccessful outcome were identified using a multivariable logistic regression model. Results: Among 1748 patients, the overall proportion of successful outcomes was 58% (95% confidence interval [95% CI] 56e60) (n ¼ 1015/1748), ranging from 65% (95% CI: 62e69) (n ¼ 531/814) for multidrug resistant TB to 54% (95% CI: 49e58) (n ¼ 301/563) for pre-extensively drug-resistant TB and 49% (95% CI: 44e55) (n ¼ 183/371) for extensively drug-resistant TB. Results were similar across oblasts, with few exceptions. The strongest risk factors for an unsuccessful outcome were extensively drug-resistant TB (adjusted OR [aOR] 3.23; 95% CI: 1.88e5.53), total serum protein below 62 g/L in adults and below 57 g/L for children and adolescents (aOR 2.79; 95% CI: 1.93e4.04), psychiatric illness (aOR 2.79; 95% CI: 1.46 e5.33), age at TB diagnosis >65 years (aOR 2.50; 95% CI: 1.42e4.42), and alcohol misuse (aOR 2.48; 95% CI: 1.89e3.26). Discussion: The overall proportion of successful outcomes among Ukrainians treated for highly drug resistant TB was 58%, notably better compared with previous years, but still low for extensively drug resistant TB. Risk factors for unsuccessful outcomes highlight that addressing socioeconomic factors in TB management is crucial. Efforts in maintaining TB dispensaries during and following the ongoing war are highly warranted.