Evidence of increased expression of Ki-67 proliferation protein and intensification of the neovascularization process in endometrial biopsies with underlying myometrium in adenomyosis and under conditions of combination of adenomyosis with hyperplastic processes, endometrial, be used as a diagnostic in detecting adenomyosis, including associated with hyperplastic endometrial processes. 3D ultrasound with the definition of uterine junctional zone is an effective method of noninvasive diagnosis of adenomyosis.