Наукові праці. Кафедра внутрішньої медицини № 1
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Item The role of insulin resistance in the development of metabolic dysfunction-associated steatotic liver disease and arterial hypertension(ГО “Наукова спільнота”, WSZIA w Opolu, 2025) Zhelezniakova, Natalia; Aleksandrova, Tetiana; Molodan, Volodymyr; Panchenko, GalynaItem A clinical case review of a patient with heartburn and dysphagia(International Science Group, 2025) Vizir, Marina; Aleksandrova, Tetiana; Zakharchenko, ViktoriaItem Brugada syndrome: clinical features, diagnosis, and modern approaches to treatment(International Science Group, 2025) Kharkivska, Dariia; Vizir, Maryna; Aleksandrova, TetianaItem Deficiency of Klotho protein as a cause of linked angina in young patients with thoracalgic phenotype of gastroesophageal reflux disease(2024-10-11) Zazdravnov, A.; Pasiieshvili, Т.; Pasiyeshvili L.; Zhelezniakova, N.Item Рentraxin-3 and endothelial dysfunction parameters in patients with metabolic dysfunction-associated steatotic liver disease and arterial hypertension(ГО “Наукова спільнота”, WSZIA w Opolu, 2024) Molodan, Volodymyr; Aleksandrova, Tetiana; Molodan, Dmytro; Chervona, OksanaItem The association of systemic inflammatory biomarkers with metabolic dysfunction-associated steatotic liver disease and arterial hypertension(2024) Aleksandrova, Tetiana; Zheleznyakova, N.; Prosolenko, Kostyantyn; Vizir, Maryna; Chervona, OksanaItem Simultaneous laparoscopic surgery of cholelithiasis and hiatal hernia comorbid course(2024) Aleksandrov, Timur; Aleksandrova, TetianaThe high number of individuals affected by cholelithiasis (gallstone disease) has posed a major financial strain on society around the world. Cholelithiasis is a worldwide problem and it remains a common cause of surgical intervention, contributing substantially to health care costs. At the same time, one of the common disease of the gastrointestinal tract is hiatal hernia. In modern surgery, laparoscopic methods of cholelithiasis and HH treatment have a number of advantages compared to traditional laparotomy methods. However, the requirements of modern surgery are not only thorough diagnosis and performance of high-tech operations, but also the achievement of rapid postoperative rehabilitation of patients, improvement of the quality of life along with maximum comfort for the patient. In this regard, simultaneous laparoscopic surgery may be the method of choice for surgical treatment of cholelithiasis and hiatal hernia comorbid course by performing simultaneous laparoscopic surgery. The aim of the study was to improve the surgical treatment of cholelithiasis and hiatal hernia comorbid course by performing simultaneous laparoscopic surgery.Item Endothelial dysfunction indicators in patients with a comorbid course of metabolic dysfunction-associated steatotic liver disease and arterial hypertension(2024) Aleksandrova, Tetiana; Popov, MaksymItem Therapeutic potential of sodium selenite in patients with non-alcoholic fatty liver disease and hypertension disease(2023-06) Tverezovska, Iryna; Zhelezniakova, NataliaLiver parenchyma damage is associated with significant activation of oxidative stress. Correction of oxidative stress can be a promising direction in the treatment of arterial hypertension. It has been established that in patients with hepatopathies, lower concentrations of selenium are found in blood and erythrocytes, which gives reason to consider selenium as a potential therapeutic agent in patients with liver pathology.Objective — to determine the therapeutic potential of sodium selenite in patients with non-alcoholic fatty liver disease in combination with hypertension.Materials and methods. 100 patients with nonalcoholic fatty liver disease (NAFLD) were included in the study: the main group — 49 patients (67.3 % women, median age is 51.0 years) with concomitant NAFLD and arterial hypertension (HTN), the comparison group — 51 patients (58.8 % women, median age is 52.0 years) with NAFLD isolated course. The control group included 20 practically healthy people (55.0 % women, median age is 51.0 years). Among the patients of the main group, the first degree of HTN was diagnosed in 28.6 % of patients (14 people), the second degree — 71.4 % (35 people). Among these patients, 32.7 % (16 people) had the first stage of HTN, 67.3 % (33 people) had the second stage. In the main group, 55.1 % of patients had steatosis, 44.9 % had steatohepatitis. In the comparison group, 58.8 % had steatosis, 41.2 % had steatohepatitis (2 = 0.141, p= 0.707). The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured according to the standard method (kinetic method). Gamma-glutamine transpeptidase (GGTP) was measured by the enzy-matic colorimetric method, alkaline phosphatase (AP) by the colorimetric method. Selenium and selenoprotein P (Sel P) levels were determined using the immunofluorescence method. Ultrasound examination of the liver was performed according to the standard method on an empty stomach.Results. Body mass index corresponded to normal or increased body weight: in the main group — 27.8 [26.6; 28.5] kg/ m2 and 27.3 [24.2; 28.3] kg/ m2 in the comparison group, in the control group — 24.3 [21.9; 26.0] kg/ m2. In patients of the main group was determined a significant (p < 0.001) predominance of ALT levels (45 [43.0; 47.5] U/ L), AST levels (53 [51.0; 56.0] U/ L), AP levels (285.7 [217.6; 321.1] U/ L) and GGTP levels (96.2 [75.0; 108.9] U/ L) opposite to comparison group (respectively 36 [34.0; 39.0] U/ L, 41 [40.0; 45.0] U/ L, 215.5 [183.2; 246.7] U/ L and 65.5 [51.5; 76.8] U/ L) and control group levels (respectively 25.5 [24.0; 30.8] U/ L, 23 [19.3; 26.0] U/ L, 129.2 [116.9; 140.6] U/ L and 22.6 [16.1; 31.7] U/ L). A two-fold decrease in selenoprotein P levels was obtained in patients with NAFLD and HTN compared to patients with NAFLD (19.7 [8.0; 26.7] ng/ mL and 43.1 [41.3; 45.4] ng/ mL respectively, p < 0.001), and selenium in one and a half times compared to patients with NAFLD (43.5 [39.9; 49.1] g/ L and 67.2 [61.5; 77.4] g/ L respectively, p < 0.001). The highest Sel P median levels (71.0 [54.3; 76.1] ng/ ml and selenium levels (108.0 [96.9; 118.8] g/ L) registered in the control group (p < 0.001). Evaluating the data on selenium metabolism and liver tests depending on the intake of sodium selenite, a significant increase in the levels of Sel P (53.6 [43.1; 60.4] ng/ ml, p < 0.001) and selenium (89.1 [63, 4; 99.5] g/ L, p < 0.009), as well as a decrease in AST levels (41.7 [32.6; 43.2] U/ l, p < 0.001) in the group with isolated NAFLD, while in the group with NAFLD and HTN comorbid course, no significant changes in the studied parameters were detected.Conclusions. The obtained results provide a basis for sodium selenite use in the therapy of patients with NAFLD. Further research on the duration of such therapy and sodium selenite dosing regimen in patients with a comorbid course of NAFLD and HTN is a promising and relevant directionItem The experience in tuberculous spondylitis treatment taking into account the susceptibility of mycobacteria tuberculosis to antibacterial medicines(The experience in tuberculous spondylitis treatment taking into account the susceptibility of mycobacteria tuberculosis to antibacterial medicines / G. G. Golka, V. V. Vesnin, V. V. Burlaka, A. O. Oliinyk, O. G. Fadeev, E. Yu. Frolova-Romaniuk, O. V. Goptsii // Tuberculosis, Lung Diseases, HIV Infection (Ukraine). ─ 2023. ─ Vol. 1. ─ P. 29─36. ─ DOI: http://doi. org/10.30978/TB-2023-1-29., 2023-03) Golka, G.; Vesnin, V.; Burlaka, V.; Oliinyk, A.; Fadeev, O.; Frolova-Romaniuk, Elina; Goptsii, OlenaThe new method of TS treatment in the main group compared to traditional standards of surgical interventions in the control group allowed: 1) to avoid the progression of TS, the development of complications of the disease (p < 0.05) and complications related to the transplant (fractures, displacement of the autograft, cage) (p < 0.05), in the early postoperative period; 2) significantly increase the effectiveness of treatment due to an increase in excellent results (46.7 and 26.7 %, respectively) and a decrease in satisfactory (13.3 and 23.3 %) and unsatisfactory (0.0 and 10.0 %; p < 0.05) of the results in the remote terms of observation; 3) significantly shorten the inpatient stage of treatment ((96 ± 12) and (190 ± 21) bed-days; p < 0.001).