Наукові праці. Кафедра внутрішньої медицини № 1

Permanent URI for this collectionhttps://repo.knmu.edu.ua/handle/123456789/1251

Browse

Author: search.filters.author.Babak, OlegSubject: search.filters.subject.endothelial lipase

Search Results

Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    Cluster analysis of the pathogenetic relationships of metabolic parameters in patients with non-alcoholic fatty liver disease on the background of hypertension
    (2019) Babak, Oleg; Bashkirova, Anna
    The aim of the study was to conduct a cluster analysis of pathogenetic relationships between metabolic parameters, endothelial lipase levels, the severity of steatosis, and clinical parameters in patients with non-alcoholic fatty liver disease with hypertension. To analyze pathogenetic relationships, a cluster analysis was performed with the distribution of parameters into 4 clusters using the Ward's method. The most dense metabolic link by cluster analysis endothelial lipase forms with NAFLD liver fat score (2.639 cu), HbA1C (2.084 cu), total cholesterol (2.272 cu), and alcohol units (2.797 cu).
  • Thumbnail Image
    Item
    Results of correction of the hepatic steatosis on the background of hypertension and overweight with help of essential phospholipid complex
    (2019-03) Babak, Oleg; Bashkirova, Anna
    One of the unfavorable factors contributing to the forma- tion of cardiovascular risk in non-alcoholic fatty liver disease (NAFLD) on the background of hypertension is the low level of HDL cholesterol, in the metabolism of which the activity of endothelial lipase (EL) plays a leading role. The liver plays an important role in the formation of dyslipidemia and is a target for lipid metabolism disorders, representing one of the pathoge- netic stages of NAFLD formation, which dictates the search for ways of drug “support” of hepatocytes. The aim of the research was to study the effectiveness of es- sential phospholipids in the complex therapy of patients with NAFLD, hypertension and overweight, taking into account the ynamics of laboratory and instrumental examinations and EL blood level. 52 patients with NAFLD on the background of hypertension and overweight have been examined. The control group con- sisted of 20 practically healthy people. All patients were divided with accordance of age and sex. Dietary nutrition with reduction of simple carbohydrates and fats was recommended for patients and treatment with essential phospholipids for 6 months at a dose of 2 capsules 3 times a day was prescribed. 16 patients of the main group showed complete compliance till the end of the course of treatment. The concen- tration of EL was determined by the ELISA using the Aviscera Bioscience INC reagents kit (USA). The complex of essential phospholipids as additional com- ponent for diet showed an effective decrease in the severity of hepatic steatosis in combination with the reduction of insulin re- sistance, as well as the restoration of normal pathogenetic func- tional links between HDL and endothelial lipase in patients with NAFLD on background of hypertension. Thus essential phospholipids can be recommended to reduce CVD and comorbidity for all patient`s with these diseases, which was mentioned above, despite the range of steatosis.
  • Thumbnail Image
    Item
    The role of endothelial lipase in the diagnosis of cardiovascular risk in patients with non-alcoholic fatty liver disease in hypertension and insulin resistance subjects
    (2018-09) Bashkirova, Anna; Babak, Oleg
    Non-alcoholic fatty liver disease (NAFLD) is now recognized as the most common disease in hepatology, and is also often accompanied by hypertension. Insulin resistance(IR) and endothelial dysfunction, in which metabolism endothelial lipase (EL) plays a leading role, are links in a chain and play an important role in the development of cardiovascular risk (CVR). Therefore, our aim was to determine the blood levels of EL for the early detection of CVR in patients with NAFLD in hypertension and IR subjects. Increased levels of EL is inherent in all patients with NAFLD and hypertension. However, in patients with NASH and hypertension formed an additional association between the level of EL and HbA1С, which allows to consider EL as an additional predictor of CVR.