Наукові праці. Кафедра внутрішньої медицини № 1

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Author: search.filters.author.Железнякова, Наталя Мерабівнаsearch.filters.applied.f.itemlanguage: search.filters.itemlanguage.en

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    Histological features of esophagus mucous membrane changes in patients with gastroesophageal reflux disease and type 2 diabetes mellitus
    (2020) Карпенко, Ірина Іванівна; Железнякова, Наталя Мерабівна; Фролова-Романюк, Еліна Юріївна; Karpenko, Iryna; Frolova-Romaniuk, Elina; Zhelezniakova, Natalia
    The high medical and social significance of type 2 diabetes mellitus (T2DM) is not only due to its prevalence, but also to serious complications that lead to a decrease in the quality of patient’s life, early disability, and high mortality.
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    Non-alcoholic fatty liver disease and hypertension: clinical variability of comorbidity
    (2020-11) Рождественська, Анастасія Олександрівна; Железнякова, Наталя Мерабівна; Rozhdestvenska, Anastasiia; Babak, Oleg; Zhelezniakova, Natalia
    Introduction. Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases, and considerable attention is paid to the comorbidity of NAFLD with hypertension (HT), which affects around one-third of the world's population. The combination of NAFLD with hypertension has been suggested to have a mutual potentiating effect, and hypertension affects the severity of NAFLD. The purpose: to study the features of the clinical manifestation of NAFLD in patients with hypertension. Materials and methods. The study included 115 patients with NAFLD at the stage of nonalcoholic steatohepatitis. The main group consisted of 63 patients with NAFLD and HT, the comparison group included 52 patients with isolated NAFLD, and the control group was composed of 20 healthy volunteers. Patients underwent anthropometric measurements, evaluation of biochemical markers of liver functional activity, lipid profile and carbohydrate metabolism changes, C-reactive protein (CRP) levels. Results. A significant increase in the proportion of patients with active complaints in the group of patients with NAFLD with HT (subjective signs of liver damage, manifestations of dyspeptic and asthenic syndrome) was detected. Significant differences were found in almost all anthropometric indicators in both groups of patients with NAFLD in comparison with the control group. The level of CRP had significant differences and was 7.90 mg/l (95% CI = 7.96-8.75 mg/l), 6.55 mg/l (95% CI = 6.47-7.57 mg/l) and 2.07 (95% CI = 1.83-2.85 mg/l) in patients with NAFLD and HT, isolated NAFLD and the control group, respectively (p <0.001). Fasting glucose levels were significantly higher in both groups of examined patients with NAFLD compared with controls. Significant differences were found in the levels of total cholesterol, VLDL cholesterol, HDL cholesterol and atherogenic factor in patients with NAFLD depending on concomitant HT. There was no significant difference between LDL cholesterol and triglycerides in the two groups of patients with NAFLD. Conclusions. Based on the obtained data, it can be stated that GC in patients with NAFLD determines important deviations in the clinical manifestation of the disease and can be considered as a trigger factor for the progression of NAFLD.
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    Показники стану ендотелію у хворих на гіпертонічну хворобу та ожиріння залежно від поліморфізмів генів PPARА та PPARG
    (Publishing House WSZiA, 2015-10) Babak, Oleg; Zhelezniakova, Natalia; Molodan, Volodymyr; Andrieieva, Anastasiia; Prosolenko, Kostyantyn; Zelena, Iryna; Yarmysh, Natalia; Бабак, Олег Якович; Железнякова, Наталя Мерабівна; Молодан, Володимир Ілліч; Андрєєва, Анастасія Олександрівна; Просоленко, Костянтин Олександрович; Зелена, Ірина Іванівна; Ярмиш, Н.В.
    The aim of the study was assessment of the optimization of the endothelium in hypertensive patients with obesity by identifying the gene polymorphisms piroksosomalnyh receptors (PPAR and PPARG) in combination with inflammation factors. There were examinated 352 patients with hypertension and obesity. Patients matched for age and sex. ELISA was determined the level of CRP, TNF-a, endothelin-1, nitric oxide (eNOs, NOx), IL-4, immunoreactive insulin in the serum. The gene polymorphisms of PPARA and PPARG studying by the polymerase chain reaction. The intima-media complex of common carotid artery measuring by echocardiography on the diagnostic complex «Ultrasound scanner» (USA). The obtained results indicate that patients - carriers 162Val allele gene PPAR observed more reduction endothelium-dependent vasodilation and simultaneous increase of endothelin-1 and metabolite concentration NOx, which is evidence of more severe violations of the functional state of the endothelium. If detected genotype Pro12Pro determined by the thickness of intima-media of common carotid artery, it would indicate an earlier development of atherosclerotic process. There is a significant difference between the metabolite concentrations of NOx and systemic inflammation in patients with genotypes Leu/Leu gene PPAR.
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    Certain pathogenetic mechanisms of systemic inflammation in patients with comorbidity of chronic obstructive pulmonary disease and chronic pancreatitis
    (2015) Zhelezniakova, Natalia; Железнякова, Наталя Мерабівна; Zelena, Iryna; Зелена, Ірина Іванівна; Pasiieshvili, Tamara; Пасієшвілі, Тамара Мерабівна