Наукові праці. Кафедра внутрішньої медицини № 1
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Item Тhe role of pentraxin-3 in non-invasive diagnosis of liver fibrosis in patients with non-alcoholic fatty liver disease(2020) Бабак, Олег Якович; Александрова, Тетяна Миколаївна; Aleksandrova, Tetiana; Babak, OlegThe aim of the study: to determine the diagnostic value of Pentraxin-3 for the stages of fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). Materials and Methods: 40 patients with NAFLD were examined, the mean age was (38.0 ± 4.1) years. The control group was created by 20 healthy individuals. There were no statistically significant differences in gender and age distribution of groups. Transient electrography of the liver was performed using an ultrasound scanner - SIEMENS - ACUSON S 3000. Determination of the level of pentraxin-3 in blood plasma was performed using the enzyme-linked immunosorbent assay using the ELISA kit. Results and Discussion: It was found that the level of Pentraxin-3 depend on the degree of liver fibrosis stage in patients with NAFLD. There was a significant increase of studied biomarker in the case of progression of liver fibrosis stage. Thus, in patients with liver fibrosis stage F0 the level of pentraxin-3 was (254, 35±44, 4) pg/ml, stage F1 – (421, 9±31, 46) pg/ml, and in stage F2 - respectively (430,9±35,86) pg/ml (p<0.05). Conclusion: In patients with NAFLD, the blood plasma’s level of Pentraxin-3 had a significant tendency to increase with the progression of the liver fibrosis stage (p<0.05), which confirms the possibility of using this biomarker in the diagnosis of liver fibrosis stagesItem Показники стану ендотелію у хворих на гіпертонічну хворобу та ожиріння залежно від поліморфізмів генів PPARА та PPARG(Publishing House WSZiA, 2015-10) Babak, Oleg; Zhelezniakova, Natalia; Molodan, Volodymyr; Andrieieva, Anastasiia; Prosolenko, Kostyantyn; Zelena, Iryna; Yarmysh, Natalia; Бабак, Олег Якович; Железнякова, Наталя Мерабівна; Молодан, Володимир Ілліч; Андрєєва, Анастасія Олександрівна; Просоленко, Костянтин Олександрович; Зелена, Ірина Іванівна; Ярмиш, Н.В.The aim of the study was assessment of the optimization of the endothelium in hypertensive patients with obesity by identifying the gene polymorphisms piroksosomalnyh receptors (PPAR and PPARG) in combination with inflammation factors. There were examinated 352 patients with hypertension and obesity. Patients matched for age and sex. ELISA was determined the level of CRP, TNF-a, endothelin-1, nitric oxide (eNOs, NOx), IL-4, immunoreactive insulin in the serum. The gene polymorphisms of PPARA and PPARG studying by the polymerase chain reaction. The intima-media complex of common carotid artery measuring by echocardiography on the diagnostic complex «Ultrasound scanner» (USA). The obtained results indicate that patients - carriers 162Val allele gene PPAR observed more reduction endothelium-dependent vasodilation and simultaneous increase of endothelin-1 and metabolite concentration NOx, which is evidence of more severe violations of the functional state of the endothelium. If detected genotype Pro12Pro determined by the thickness of intima-media of common carotid artery, it would indicate an earlier development of atherosclerotic process. There is a significant difference between the metabolite concentrations of NOx and systemic inflammation in patients with genotypes Leu/Leu gene PPAR.Item Вплив гормонів жирової тканини на перебіг гіпертонічної хвороби(2012) Бабак, Олег Якович; Терешкін, Костянтин Ігорович