Наукові праці. Кафедра внутрішньої медицини № 1
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Item Arterial hypertension and non-alcoholic fatty liver disease: adipokine activity(2017) Goptsii, Olena; Buriakovska, Olena; Vovchenko, Maryna; Reznik, LarisaThe leptin level, TNF-α and the HOMA-IR index (leptin 12.73±0.82 ng/ml, female patients: 12.93±0.99 ng/ml, male patients: 11.92±1.23 ng/ml; TNF-α 8.40±0.44 mg/ml; HOMA-IR index 4.09±0.49 CU) were significantly higher in the patients patients with AH and NAFLD with AO than such of the patients with AH and NAFLD without AO: (leptin 6.66±0.48 ng/ml, female patients: 6.25±1.19 ng/ml, male patients: 6.78±0.53 ng/ml; TNF-α 5.31±0.37 ng/ml; HOMA-IR index 2.0±0.22 CU). Conclusion. The levels of leptin, TNF-α and insulin resistance index were elevated statistically significant in patients with AH and NAFLD with AO.Item Eating behavioral reactions of patients with chronic non-communicable diseases and its correction(2019) Shalimova, Anna; Isayeva, Ganna; Vovchenko, Maryna; Rieznik, L.; Buriakovska, Olena; Emelyanova, N.The peculiarities of the eating behavioral reactions of patients with chronic non-communicable diseases and the effect of group and individual therapy on them were evaluated. It was established, that with a tendency to positive changes in eating behavior, conducting both group and individual therapy for 1 year did not significantly change its indicators such as daily consumption of salt, vegetables and fruits, smoking and alcohol consumption, which confirms the complexity of the impact on the specified risk factor for the development and progression of chronic non-communicable diseases.Item Effect of amlodipine on the manifestations of chronic insomnia in hypertensive patients with type 2 diabetes mellitus(2020) Isayeva, Ganna; Buriakovska, Olena; Shalimova, AnnaBackground: The aim of the study was to assess the association between antihypertensive therapy and the manifestations of insomnia in patients with arterial hypertension (AH) and type 2 diabetes mellitus (T2DM). Material and methods: The study included 120 hypertensive patients with and without T2DM (among them there were 60 patients with insomnia). The study consisted of three stages. The first stage was conducted as a cross-sectional study, during which an association was established between different antihypertensive products and the presence of insomnia in the study population. The second and third stages were a prospective study, during which a modification of the therapy to reduce the manifestations of insomnia was performed. Results: It was found that patients receiving amlodipine in the combination antihypertensive therapy had insomnia manifestations much less frequently as compared to indapamide. A statically significant decrease in blood pressure (BP) and a higher proportion of patients with target BP were observed in both groups. Replacement of indapamide with amlodipine was shown to improve sleep quality. Thus, the number of patients with insomnia significantly decreased in both groups. After correction of antihypertensive therapy after 12 months, all patients were assessed for sleep disorders. The incidence of insomnia was found to be significantly reduced in both groups after changing therapy from indapamide to amlodipine. Conclusions: Correction of antihypertensive therapy, namely the replacement of indapamide with amlodipine, contributes to an improvement in BP, quality of life, and a reduction in the proportion of patients with insomnia.Item The effect of physical activity enlargement on anthropometric parameters and blood lipids depending on genetic polymorphisms of beta-2 and beta-3 adrenoreceptors(2020) Isayeva, Ganna; Shalimova, Anna; Vovchenko, Maryna; Buriakovska, Olena; Galchinska, V.Assessment of genetic factors, which determine the effect of physical exercise, allows to identify individuals that are not susceptible to positive effects of enlargement of physical activity. The aim of the study was to assess the effect of enlargement of physical activity on anthropometric parameters and blood lipids in individuals with- out cardiovascular diseasesItem The impact of sleep disorders in the formation of hypertension(2022) Isayeva, Ganna; Buriakovska, Olena; Shalimova, AnnaHypertension is one of the most common chronic non-communicable diseases in the world. Risk factors, methods of prevention and treatment of hypertension have been sufficiently studied. However scientists are still looking for pathogenetic mechanisms of its development. At the same time, 36.9% of patients with hypertension had different sleep disorders. Patients with insomnia have a 21% higher risk of developing hypertension compared with those who have quality sleep. Hypnotics are given up to 15% of patients with hypertension. Hypnotics have been shown to increase the risk of cardiovascular events. As much as 44.1% of patients with established diseases of the cardiovascular system have problems with the quality or duration of sleep. At this time, hypertension and sleep disorders are considered mutually aggravating diseases.Item Level of TNF-α depending on the presense of insulin resistance in patients with arterialhypertenion and obsity(2016) Goptsii, Olena; Vovchenko, Maryna; Buriakovska, Olena; Reznik, LarisaWas established that the level of TNF-α in the blood of patients with hypertensive insulin resistance was significantly higher than among patients without hypertensive insulin resistanceItem Metabolic disorders in hypertensive patients with nonalcoholic fatty liver disease(2017) Goptsii, Olena; Buriakovska, OlenaResults of our study indicate statistically significant elevation of leptin and HOMA index in hypertensive patients with NAFLD and positive statistically significant correlations between these parameters.