Наукові праці. Кафедра внутрішньої медицини № 1

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    Correlation between vascular remodeling and level of adipokine visfatin in hypertensive patients combined with abdominal obesity
    (2015-03) Andrieieva, Anastasiia
    Aim of the study is to optimize diagnosis of hypertensive patients combined with abdominal obesity (AO) and without it based on the determined effect of visfatin on vascular lesions. Methods. A total patients were completed 84 hypertensive patients which were separated on the first group patients with hypertension (n=25) and the second group of hypertensive patients with AO (n=59), the third group were control of apparently healthy individuals (n=17). Patients matched for age and sex. ELISA «RayBioteeh», USA was determined the level of visfatin in the serum. Structural condition of the common carotid artery evaluated by measuring the intima-media complex (IMC) of common carotid artery (CCA) used the echocardiography on the diagnostic complex «Ultrasound scanner» (USA). . Result. The systolic blood pressure (SBP) was completed (177,8±3,7) mm Hg for hypertensive patients with abdominal obesity and hypertensive patients for (166,4±2,9) mm Hg (p<0.05). In patients with abdominal obesity the level of visfatin significantly different from the control group by (33,9±1,47) ng/ml and (17,51±0,96) ng/ml (p<0.05), while in the group of hypertensive patients (24,27±1,2) ng/ml, significant differences were not found. Visfatin levels in hypertensive patients with AO (25,43±1,48) ng/ml, in contrast to patients with hypertension (19,49 ± 1,16) ng/ml, even at normal of IMC of the CCA were significantly different from the control group (p<0.05). Established a positive correlation between visfatin and IMC of the CCA in hypertension with abdominal obesity (r=0,49) and without (r=0,41), p <0,05. Conclusion. The results shows that elevated serum visfatin levels are early lesion of the vascular bed makes higher levels of visfatin compared with the control group with hypertension and AO on a background of normal IMC of the vascular wall.
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    Visfatin level in hypertensive patients with abdominal obesity against the combination of anti-hypertensive therapy and atorvastatin
    (2014-09) Andrieieva, Anastasiia
    The treatment of hypertensive patients with abdominal obesity and dyslipidemia considering the dynamics of the visfatin level in the blood serum receiving combination of anti-hypertensive therapy and atorvastatin is relevant.
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    Показники стану ендотелію у хворих на гіпертонічну хворобу та ожиріння залежно від поліморфізмів генів PPARА та PPARG
    (Publishing House WSZiA, 2015-10) Babak, Oleg; Zhelezniakova, Natalia; Molodan, Volodymyr; Andrieieva, Anastasiia; Prosolenko, Kostyantyn; Zelena, Iryna; Yarmysh, Natalia; Бабак, Олег Якович; Железнякова, Наталя Мерабівна; Молодан, Володимир Ілліч; Андрєєва, Анастасія Олександрівна; Просоленко, Костянтин Олександрович; Зелена, Ірина Іванівна; Ярмиш, Н.В.
    The aim of the study was assessment of the optimization of the endothelium in hypertensive patients with obesity by identifying the gene polymorphisms piroksosomalnyh receptors (PPAR and PPARG) in combination with inflammation factors. There were examinated 352 patients with hypertension and obesity. Patients matched for age and sex. ELISA was determined the level of CRP, TNF-a, endothelin-1, nitric oxide (eNOs, NOx), IL-4, immunoreactive insulin in the serum. The gene polymorphisms of PPARA and PPARG studying by the polymerase chain reaction. The intima-media complex of common carotid artery measuring by echocardiography on the diagnostic complex «Ultrasound scanner» (USA). The obtained results indicate that patients - carriers 162Val allele gene PPAR observed more reduction endothelium-dependent vasodilation and simultaneous increase of endothelin-1 and metabolite concentration NOx, which is evidence of more severe violations of the functional state of the endothelium. If detected genotype Pro12Pro determined by the thickness of intima-media of common carotid artery, it would indicate an earlier development of atherosclerotic process. There is a significant difference between the metabolite concentrations of NOx and systemic inflammation in patients with genotypes Leu/Leu gene PPAR.