Наукові праці. Кафедра внутрішньої медицини № 1
Permanent URI for this collectionhttps://repo.knmu.edu.ua/handle/123456789/1251
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Item Brugada syndrome: clinical features, diagnosis, and modern approaches to treatment(International Science Group, 2025) Kharkivska, Dariia; Vizir, Maryna; Aleksandrova, TetianaItem Modern methods of diagnosis and screening of non-alcoholic fatty liver disease and its stages (review)(2022) Zhelezniakova, Natalia; Babak, Oleg; Aleksandrova, TetianaThe review features the problem of diagnosing one of the most common pathologies of the contemporary world –non-alcoholic fatty liver disease (NAFLD). Data from experimental and clinical studies on the importance of various instrumental and biochemical methods of non-invasive diagnosis of non-alcoholic steatohepatitis (NASH) and liver fibrosis (LF) are pre-sented. New non-invasive diagnostic methods of NASH and LF are discussed.Item Simultaneous laparoscopic surgery of cholelithiasis and hiatal hernia comorbid course(2024) Aleksandrov, Timur; Aleksandrova, TetianaThe high number of individuals affected by cholelithiasis (gallstone disease) has posed a major financial strain on society around the world. Cholelithiasis is a worldwide problem and it remains a common cause of surgical intervention, contributing substantially to health care costs. At the same time, one of the common disease of the gastrointestinal tract is hiatal hernia. In modern surgery, laparoscopic methods of cholelithiasis and HH treatment have a number of advantages compared to traditional laparotomy methods. However, the requirements of modern surgery are not only thorough diagnosis and performance of high-tech operations, but also the achievement of rapid postoperative rehabilitation of patients, improvement of the quality of life along with maximum comfort for the patient. In this regard, simultaneous laparoscopic surgery may be the method of choice for surgical treatment of cholelithiasis and hiatal hernia comorbid course by performing simultaneous laparoscopic surgery. The aim of the study was to improve the surgical treatment of cholelithiasis and hiatal hernia comorbid course by performing simultaneous laparoscopic surgery.Item Рentraxin-3 and endothelial dysfunction parameters in patients with metabolic dysfunction-associated steatotic liver disease and arterial hypertension(ГО “Наукова спільнота”, WSZIA w Opolu, 2024) Molodan, Volodymyr; Aleksandrova, Tetiana; Molodan, Dmytro; Chervona, OksanaItem Тhe role of pentraxin-3 in non-invasive diagnosis of liver fibrosis in patients with non-alcoholic fatty liver disease(2020) Бабак, Олег Якович; Александрова, Тетяна Миколаївна; Aleksandrova, Tetiana; Babak, OlegThe aim of the study: to determine the diagnostic value of Pentraxin-3 for the stages of fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). Materials and Methods: 40 patients with NAFLD were examined, the mean age was (38.0 ± 4.1) years. The control group was created by 20 healthy individuals. There were no statistically significant differences in gender and age distribution of groups. Transient electrography of the liver was performed using an ultrasound scanner - SIEMENS - ACUSON S 3000. Determination of the level of pentraxin-3 in blood plasma was performed using the enzyme-linked immunosorbent assay using the ELISA kit. Results and Discussion: It was found that the level of Pentraxin-3 depend on the degree of liver fibrosis stage in patients with NAFLD. There was a significant increase of studied biomarker in the case of progression of liver fibrosis stage. Thus, in patients with liver fibrosis stage F0 the level of pentraxin-3 was (254, 35±44, 4) pg/ml, stage F1 – (421, 9±31, 46) pg/ml, and in stage F2 - respectively (430,9±35,86) pg/ml (p<0.05). Conclusion: In patients with NAFLD, the blood plasma’s level of Pentraxin-3 had a significant tendency to increase with the progression of the liver fibrosis stage (p<0.05), which confirms the possibility of using this biomarker in the diagnosis of liver fibrosis stages