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    Comparison of reproductive characteristics of women from Chernivtsi and Simferopol
    (2018) Kozak, N.; Antsupova, V.; Mustafaeva, L.
    Reproductive characteristics were calculated for the residents of Chernivtsi and the residents of Simferopol of post-productive age according to the data of the obstetric-gynecologic anamnesis. The average number of pregnancies and their outcomes for the representatives of these cities were count for two generations. Statistical differences between populations were found by the percentage of women who had medical abortions, miscarriages and stillbirths. Significant difference was found for the percentage of artificially interrupted pregnancies and the realized zygotes.
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    Successful rehabilitation of patient disabled by the autistic spectrum disorder and the modified epigenetic status (polymorphisms DRD2 2137 T/T, MTRR 66 A/G, MTHFR 677 C/T, MTHFR 1298 A/C) – case report
    (2019) Grechanina, Juliya; Bugaeva, E.; Lisniak, S.; Staruseva, V.; Shmulich, O
    Autism spectrum disorders (ASD) are considered an epidemic - only in the last 5 years the incidence of pathology has increased from 1: 166 to 1:68 children. The main role in the pathogenesis of ASD currently belongs to the violation of the epigenetic status in the form of gene polymorphisms. An example is the olymorphic variants of the genes of the folate-methionine cycle enzymes, which regulate the epigenetic status through a methylation process. The article presents a case of autism spectrum disorder against the background of impaired epigenetic status (metabolic dopamine neurotransmitters and the methylation cycle). Individually selected metabolic correction based on biochemical parameters allowed improving behavior, stimulating speech development, stopping long subfebrile and hypersalivation.
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    Effects of Non-Allelic Interactions of O2 and SU2 Mutant Genes on Grain Biochemical Composition in Various Corn Inbreds
    (2023-10-31) Tymchuk, Dmytro; Sadovnychenko, Iurii; Tymchuk, Natalia; Pasiuga, Olga
    The use of combinations of non-allelic mutant genes of the maize endosperm structure creates opportunities for improving the quality of corn grain in comparison not only with forms of the common type but also with monogenic endospermic mutants. In this study, the effect of a combination of mutant genes O2 (Opaque-2) and SU2 (Sugary-2) according to the biochemical composition of the grain was studied. For the research, a series of inbreds - carriers of a combination of mutant genes O2SU2, inbreds - carriers of monogenic mutations O2 and SU2, as well as maize inbreds of the common type of two-year reproduction were used. In the experiments, the content of protein, starch, and oil and the main characteristics of their quality were studied. It was found that the inbred carriers of the O2SU2 combination are superior to the inbred carriers of monogenic mutations O2 and SU2 in terms of complex biochemical characteristics. In comparison with mutants O2 they were distinguished by an increased content of protein (by 12.3% on average), amylose in starch (by 38.9% on average), starch digestibility (by 24.4% on average), oil content (by 18.4% on average) and oleate content in oil (by 29.9% on average). In comparison with the carriers of SU2 mutation, they had a higher content of lysine and tryptophan in the total grain protein (on average, by 19.4% & 14.3%, respectively). The main characteristics of grain quality in carriers of a combination of mutant genes O2SU2 were characterized by quantitative variability, which can modify the effect of non–allelic interaction of mutant genes O2 and SU2. The obtained results indicate the effectiveness of using non-allelic interactions between the O2 and SU2 mutant genes to improve the quality of corn grain.
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    The effect of surface treatment of ceramic oxide coatings deposited by magnetron sputtering method on the adhesive and proliferative activity of mesenchymal stem cells
    (2016) Zykova, A.; Safonov, V.; Goltsev, A.; Dubrava, T.; Rossokha, I.; Smolik, J.; Rogovska, R.; Yakovin, S.; Kolesnikov, D.; Sudzhanskaya, I.; Goncharov, I.
    The effect was analyzed of surface treatment by argon ions on the surface properties of tantalum pentoxide coatings deposited by reactive magnetron sputtering. The structural pa-rameters of the as-deposited coatings were investigated by means of transmission electron mi-croscopy, atomic force microscopy and scanning electron microscopy. X-ray diffraction pro-files and X-ray photoelectron spectra were also acquired. The total surface free energy (SFE), the polar, dispersion parts and fractional polarities, were estimated by the Owens-Wendt-Rabel-Kaeble method. The adhesive and proliferative potentials of bone marrow cells were evaluated for both Ta2O5 coatings and Ta2O5 coatings deposited by simultaneous bombardment by argon ions in in vitro tests.
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    Imbalance of pro- and anti-inflammatory cytokines in community-acquired pneumonia of children with different levels of physical development.
    (2017) Borodina, O.; Frolova, T.
    Physical development (PD) of children and adolescents reflects the pattern of body growth processes, its morphological and functional state for each age period. Despite the large number of studies in this field, the problem remains unclear concerning the peculiarities of the immune reaction to acute inflammatory process of children with different levels of PD
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    Inhabited locality related distribution of malaria in India
    (2017) Kalyan, V.; Myronova, I.; Kaur Raveena; Kaur Randhawa Anmolpreet
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    SNPS of calpain/calpastatin systemgenes in commercial population of aberdeen angus in Kharkiv Region, Eastern Ukraine
    (2016) Fedota, O.; Ruban, S.; Lysenko, N.; Kolisnyk, A.; Goraichuk, I.
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    Genetic Study of X-Linked Recessive Ichthyosis in Eastern Ukraine
    (2021) Fedota, О.; Roshcheniuk, L.; Sadovnychenko, I.; Gontar, J.; Merenkova, I.; Vorontsov, V.; Ryzhko, P.
    X-linked recessive ichthyosis (OMIM 308100) is a form of ichthyosis caused by abnormal keratinization and can result in disability, social maladaptation, and decreased quality of life for patients and their families. In most cases the disease is caused by a complete or partial deletion of the steroid sulfatase (STS) gene. This study estimated the prevalence of X-linked recessive ichthyosis, the inbreeding coefficient (or fixation index) FST, and the selection coefficient in individuals of eastern Ukraine (namely, Kharkiv oblast). The genealogical method was used to assess the genetic structure of families with a history of this disease. Fluorescent in situ hybridization (FISH) was carried out to detect the deletion of the STS gene in patients and their relatives. The prevalence of the disease in eastern Ukraine was 1.5 × 10–4 males, it ranged from 4.9 × 10–5 to 4.9 × 10–4 males in the districts, and from 2.2 × 10–4 males in the town of Krasnograd to 3.7 × 10–3 males in a village of Balakliia district. The burden of X-linked recessive ichthyosis was found to be positively correlated with the inbreeding coefficient FST in all the studied districts (r = 0.976). Over the past 10 years, the inbreeding coefficient FST increased 1.8 times and the prevalence of X-linked recessive ichthyosis increased 1.4–4.3 times in most districts of the region.
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    The effects of polymorphisms in calpain, calpastatin and growth hormone genes on growth traits in Angus cows
    (2016) Ruban, S.; Fedota, O.; Lysenko, N.; Kolisnyk, A.; Goraichuk, I.
    The study was aimed to determine the allele and genotype frequencies of SNPs for gene calpain (CAPN316), calpastatin (CAST282) and growth hormone (GH L127V) in Aberdeen-Angus (n=52) and to evaluate their impact on body weight dynamics until age of 5 years. The allele and genotype frequencies was CAPN316: C = 0.45, G = 0.55; CC = 19.2%, CG = 51.9%, GG = 28.9%, CAST282: C = 0.75, G = 0.25; CC = 53.8%, CG = 42.3%, GG = 3.9%, GH L127V: C = 0.34, G = 0.66; CC = 9.6%, CG = 48.1%, GG = 42.3%. There is correlation between the number of C-alleles for GH L127V and increase in body weight from birth till two years. The CAPN316 and CAST282 alleles associated with meat tenderness effect on live body weight increase after two year age. A significant effect of genotype CC CAPN316 is observed at the age of three and four years. It was concluded, that selection aimed to improve meat quality does not lead to a significant reduction in live body weight.